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Merck
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Fontos dokumentumok

SRP3059

Sigma-Aldrich

Interferon-λ human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

Szinonimák:

IFN-λ human, IL-29

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez


About This Item

UNSPSC kód:
12352202
NACRES:
NA.32

biológiai forrás

human

rekombináns

expressed in E. coli

Teszt

≥98% (HPLC)
≥98% (SDS-PAGE)

Forma

lyophilized

hatékonyság

0.2-0.5 ng/mL ED50

molekulatömeg

19.8 kDa

kiszerelés

pkg of 20 μg

technika/technikák

cell culture | mammalian: suitable

szennyeződések

<0.1 EU/μg endotoxin, tested

szín

white to off-white

UniProt elérési szám

kiszállítva

wet ice

tárolási hőmérséklet

−20°C

Géninformáció

human ... IL29(282618)

Általános leírás

IFN-λ-1,-2, and -3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family of interferons. All three IFN-λs use a distinct receptor system composed of an IFN-λR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14). Signaling through this receptor system induces antiviral defense similar but distinct than the type I Interferons. Recombinant human IFN-L1 is a 19.8kDa protein containing 178 amino acid residues.

Biokémiai/fiziológiai hatások

Interleukin-29 (IL-29) enhances the production of interleukins from monocytes. It has been observed that it stimulates antiviral responses to herpes simplex virus 1 in vitro. Serums from patients with rheumatoid arthritis have high levels of IL29.

Szekvencia

PTSKPTTTGK GCHIGRFKSL SPQELASFKK ARDALEESLK LKNWSCSSPV FPGNWDLRLL QVRERPVALE AELALTLKVL EAAAGPALED VLDQPLHTLH HILSQLQACI QPQPTAGPRP RGRLHHWLHR LQEAPKKESA GCLEASVTFN LFRLLTRDLK YVADGNLCLR TSTHPEST

Fizikai forma

Lyophilized from 1x PBS.

Feloldás

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.5-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 3

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable


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Analitikai tanúsítványok (COA)

Lot/Batch Number

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Dokumentumtár megtekintése

Expression of human immune interferon cDNA in E. coli and monkey cells.
P W Gray et al.
Nature, 295(5849), 503-508 (1982-02-11)
Vivienne A Ezzat et al.
Diabetes, obesity & metabolism, 10(3), 198-211 (2008-02-14)
Patients with insulin resistance and type 2 diabetes have an excessive risk of cardiovascular disease (CVD); this increased risk is not fully explained by traditional risk factors such as hypertension and dyslipidaemias. There is now compelling evidence to suggest that
K Lopušná et al.
Acta virologica, 58(4), 325-332 (2014-12-19)
Lambda interferons (IFN-λ) are known to induce potent antiviral response in a wide variety of target cells. They activate the same intracellular signalling pathways and have similar biological activities as IFN-α/β, including antiviral activity, but signal via distinct receptor complex
Qian Wu et al.
Autoimmunity, 46(1), 40-43 (2012-10-09)
Interferon (IFN)-λ1 is a newly described cytokine that is known for its proinflammatory activity in viral infection and in cancer. Because recent studies indicated that IFN-λ can influence significantly the innate and adaptive immune response, we studied IFN-λ in a
Fang Wang et al.
Arthritis research & therapy, 14(5), R228-R228 (2012-10-20)
The immunoregulatory function of interleukin (IL)-29 has recently been recognized. However, little is known about the involvement of IL-29 in the pathogenesis of rheumatoid arthritis (RA). This study aimed to examine the expression profiles of IL-29 in blood, synovial fluid

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