SRP2045
PPAR, γ human
recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
Szinonimák:
CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
UNSPSC kód:
12352200
NACRES:
NA.26
Javasolt termékek
biológiai forrás
human
rekombináns
expressed in E. coli
Teszt
≥70% (SDS-PAGE)
Forma
frozen liquid
molekulatömeg
~60 kDa
kiszerelés
pkg of 10 μg
tárolási körülmény
avoid repeated freeze/thaw cycles
koncentráció
500 μg/mL
technika/technikák
ligand binding assay: suitable
szín
clear colorless
NCBI elérési szám
UniProt elérési szám
kiszállítva
dry ice
tárolási hőmérséklet
−70°C
Géninformáció
human ... PPARG(5468)
Biokémiai/fiziológiai hatások
There is evidence that a group of closely related nuclear receptors, called peroxisome proliferator-activated receptors (PPARs), may be involved in chronic diseases such as diabetes, obesity, artherosclerosis and cancer. The PPARs were first cloned as the nuclear receptors that mediate the effects of synthetic compounds called peroxisome proliferators on gene transcription. It soon became clear that eicosanoids and fatty acids can also regulate gene transcription through PPARs. They bind a specific element in the promoter region of target genes only as a heterodimer with the receptor for 9-cis retinoic acid, RXR (retinoid X receptor). Binding of the ligand of either receptor can activate the complex, but binding of both ligands simultaneously is more potent. Three PPAR isotypes have been identified: α, β (also called NUC1) and γ. PPAR α is expressed most in brown adipose tissue and liver, then kidney, heart and skeletal muscle. PPAR β is found in many tissues but the highest expression is in the gut, kidney and heart. PPAR γ is mainly expressed in adipose tissue, and to a lesser extent in colon, the immune system and the retina. The target genes of PPAR α are a relatively homogenous group of genes that participate in aspects of lipid catabolism such as fatty acid uptake through membranes, fatty acid binding in cells, fatty acid oxidation (in microsomes, peroxisomes and mitochondria) and lipoprotein assembly and transport.
Fizikai forma
Clear and colorless frozen liquid solution
Elkészítési megjegyzés
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
Tárolási osztály kódja
12 - Non Combustible Liquids
WGK
WGK 1
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
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Analitikai tanúsítványok (COA)
Lot/Batch Number
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E D Rosen et al.
Molecular cell, 4(4), 611-617 (1999-11-05)
The process of adipogenesis is known to involve the interplay of several transcription factors. Activation of one of these factors, the nuclear hormone receptor PPAR gamma, is known to promote fat cell differentiation in vitro. Whether PPAR gamma is required
Ho Sun Jung et al.
Yonsei medical journal, 52(1), 165-172 (2010-12-15)
Imbalances between osteogenic and adipogenic differentiation leads to diseases such as osteoporosis. The aim of our study was to demonstrate the differences in extracellular signal-regulated kinase (ERK) phosphorylation during both adipogenesis and osteogenesis of human bone marrow-derived stem cells (BMSCs).
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
B Desvergne et al.
Endocrine reviews, 20(5), 649-688 (1999-10-26)
S Kersten et al.
Nature, 405(6785), 421-424 (2000-06-06)
In developed societies, chronic diseases such as diabetes, obesity, atherosclerosis and cancer are responsible for most deaths. These ailments have complex causes involving genetic, environmental and nutritional factors. There is evidence that a group of closely related nuclear receptors, called
Tudóscsoportunk valamennyi kutatási területen rendelkezik tapasztalattal, beleértve az élettudományt, az anyagtudományt, a kémiai szintézist, a kromatográfiát, az analitikát és még sok más területet.
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