SML1192

SB290157 trifluoroacetate salt

≥97% (HPLC)

• Szinonimák: N2-[2-(2,2-Diphenylethoxy)acetyl]-L-arginine trifluoroacetate salt, SB 290157 trifluoroacetate salt
• Tapasztalati képlet (Hill-képlet): C₂₂H₂₈N₄O₄ · CF₃CO₂H
• CAS-szám: 1140525-25-2
• Molekulatömeg: 526.51
• UNSPSC kód: 12352200
• PubChem Substance ID: 329825711
• NACRES: NA.77

Tulajdonságok

• Minőségi szint: 100
• Teszt: ≥97% (HPLC)
• form: powder
• optikai aktivitás: [α]/D +1.5 to +5°, c = 1.0 in DMSO
• tárolási körülmény: desiccated
• szín: white to beige
• oldhatóság: DMSO: 10 mg/mL, clear
• tárolási hőmérséklet: −20°C
• SMILES string: NC(NCCC[C@@H](C(O)=O)NC(COCC(C1=CC=CC=C1)C2=CC=CC=C2)=O)=N.FC(F)(C(O)=O)F
• InChI: 1S/C22H28N4O4.C2HF3O2/c23-22(24)25-13-7-12-19(21(28)29)26-20(27)15-30-14-18(16-8-3-1-4-9-16)17-10-5-2-6-11-17;3-2(4,5)1(6)7/h1-6,8-11,18-19H,7,12-15H2,(H,26,27)(H,28,29)(H4,23,24,25);(H,6,7)/t19-;/m0./s1
• Nemzetközi kémiai azonosító kulcs: ZJRMPPVJAQWGEG-FYZYNONXSA-N

Leírás

Biokémiai/fiziológiai hatások

SB290157 is a selective antagonist of complement anaphylatoxin C3a receptor, a 74 amino acid proinflammatory peptide that is a potent chemotaxin for eosinophils, macrophages and mast cells, and has recently been found to be involved in nonimmunological roles in osteoblast differentiation, angiogenesis, and lipid metabolism. SB290157 is selective for C3aR over C5aR or other chemotactic GPCRs with an IC50 of 200 nM. It effectively blocks C3aR in humans, rat, guinea pig, and mouse.SB290157 was found to inhibit diet-induced obesity, metabolic dysfunction, and adipocyte signaling, in addition to inhibiting macrophage signaling.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable