SML0539

T863

≥98% (HPLC)

• Szinonimák: 2-((1,4-trans)-4-(4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)- phenyl)cyclohexyl)acetic acid, T-863, trans-4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]-cyclohexaneacetic acid
• Tapasztalati képlet (Hill-képlet): C₂₂H₂₆N₄O₃
• CAS-szám: 701232-20-4
• Molekulatömeg: 394.47
• MDL-szám: MFCD11977270
• UNSPSC kód: 51111800
• PubChem Substance ID: 329825541
• NACRES: NA.77

Tulajdonságok

• Minőségi szint: 100
• Teszt: ≥98% (HPLC)
• Forma: powder
• szín: white to beige
• oldhatóság: DMSO: 15 mg/mL (clear solution)
• tárolási hőmérséklet: 2-8°C
• SMILES string: CC1(C)Oc2ncnc(N)c2N=C1c3ccc(cc3)[C@@H]4CC[C@H](CC4)CC(O)=O
• InChI: 1S/C22H26N4O3/c1-22(2)19(26-18-20(23)24-12-25-21(18)29-22)16-9-7-15(8-10-16)14-5-3-13(4-6-14)11-17(27)28/h7-10,12-14H,3-6,11H2,1-2H3,(H,27,28)(H2,23,24,25)/t13-,14-
• Nemzetközi kémiai azonosító kulcs: FUIYMYNYUHVDPT-HDJSIYSDSA-N

Leírás

Alkalmazás

T863 has been used as a diglyceride acyltransferase (DGAT1) inhibitor:

• to provide the opportunity to precisely control the DGAT inhibition
• to treat mouse embryonic fibroblasts (MEFs) to analyse lipid droplet biogenesis
• to specifically block neutral lipid synthesis and lipid droplet formation in HT-1080 cells
• to block lipid droplet (LD) formation

Biokémiai/fiziológiai hatások

T863 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. T863 causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice.

T863 is an orally active, selective and potent DGAT1 inhibitor.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable