SMB00378

Diallyl disulfide

≥98% (HPLC)

• Szinonimák: Allyl disulfide, Diallyl disulfide
• Lineáris képlet: CH₂=CHCH₂SSCH₂CH=CH₂
• CAS-szám: 2179-57-9
• Molekulatömeg: 146.27
• Beilstein: 1699241
• EC-szám: 218-548-6
• MDL-szám: MFCD00008656
• UNSPSC kód: 12352200
• PubChem Substance ID: 329824979
• NACRES: NA.25

Tulajdonságok

• biológiai forrás: Allium sativum L.
• Minőségi szint: 200
• gőzsűrűség: >5 (vs air)
• gőznyomás: 1 mmHg ( 20 °C)
• Teszt: ≥98% (HPLC)
• Forma: oil
• szín: colorless to yellow
• törésmutató: n20/D 1.541 (lit.)
• bp: 180-195 °C (lit.)
• sűrűség: 1.008 g/mL at 25 °C (lit.)
• alkalmazás(ok): metabolomics; vitamins, nutraceuticals, and natural products
• tárolási hőmérséklet: −20°C
• SMILES string: C=CCSSCC=C
• InChI: 1S/C6H10S2/c1-3-5-7-8-6-4-2/h3-4H,1-2,5-6H2
• Nemzetközi kémiai azonosító kulcs: PFRGXCVKLLPLIP-UHFFFAOYSA-N

Leírás

Általános leírás

Diallyl disulfide (DADS) is an oil-soluble volatile organosulfur compound that can be naturally found in Allium sativum (garlic). It has a simple chemical structure with two sulfur atoms attached with two allyl groups. This constitute of garlic contributes to its pungent aroma.

Alkalmazás

Diallyl disulfide has been used:

• to study its effects in apoptosis induction and cell viability on different glioma cell lines
• as a treatment and positive control to assess the anti-inflammatory regulation of nuclear factor erythroid-2 related factor-2 (Nrf2) in breast cancer cells
• as a potential substrate compound to detect hydrogen sulfide (H₂S) production via lead acetate/lead sulfide method

Biokémiai/fiziológiai hatások

Diallyl disulfide is a potent anticancer agent. It can reduce carcinogen-induced cancers and shows anti-proliferative effects in both in vivo and in vitro models. DADS enhances the anti-obesity and anti-inflammatory effects of green tea in high-fat/high-sucrose (HF/HS) diet-fed mice. It also displays antioxidant, anti-microbial, cardiovascular protective, and neuroprotective activities. DADS elicits anti-mitotic and anti-neoplastic effects and arrests mitosis in colon neoplastic lesions in vivo and colon tumor cell growth in vitro experiments.

Organosulfur compound that is naturally found in garlic. Contributes to the pungent odor of crushed garlic. Anticancer agent and may provide protection against cardiovascular disease.

Biztonsági adatok

• Piktogramok: GHS06
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H301,H315,H319,H335
• Óvintézkedésre vonatkozó mondatok: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Veszélyességi osztályok: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Célzott szervek: Respiratory system
• Tárolási osztály kódja: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Lobbanási pont (F): 143.6 °F - closed cup
• Lobbanási pont (C): 62 °C - closed cup