SCP0108

Cathepsin B Substrate

≥95% (HPLC), lyophilized

• Tapasztalati képlet (Hill-képlet): C₂₆H₃₆N₁₀O₆
• Molekulatömeg: 584.63
• UNSPSC kód: 12352204
• NACRES: NA.32

Tulajdonságok

• Terméknév: Cathepsin B Substrate, colorimetric,
• Teszt: ≥95% (HPLC)
• Forma: lyophilized
• összetétel: Peptide Content, ≥80%
• tárolási körülmény: protect from light
• tárolási hőmérséklet: −20°C

Leírás

Amino Acid Sequence

Z-Arg-Arg-pNA

Általános leírás

Cathepsin B, a bilobal protein, belongs to the papain-like family of cysteine proteases. It is produced as a preproenzyme. Its catalytic site is present at the interface between the two lobes. Cathepsin B has an occluding loop. It is located in the secretory vesicles of the neuronal cells. Active cathepsin B is found in the endosomal or lysosomal compartment under normal physiological conditions.

Biokémiai/fiziológiai hatások

Cathepsin B is a lysosomal cysteine proteinase that metabolizes important molecules such as β-amyloid precursor protein into harmless fragments. Cathepsin B may be detected using the chromogenic substrate Z-Arg-Arg-pNA (z-arg-arg-p-nitroanalide) or flourogenic substrate Z-Arg-Arg-AMC (z-Arg-Arg-amino-4-methylcoumarin).

Cathepsin B possesses endopeptidase and exopeptidase activity. Active cathepsin B is mostly engaged in intracellular and extracellular protein turnover, which helps cells maintain homeostatic metabolic activity. It also participates in the regulation of pro-hormone and pro-enzyme activation, antigen processing, inflammatory reactions against antigens, tissue remodeling, and apoptosis. Cathepsin B plays a key role in acute pancreatitis. It also plays a vital role in lipid metabolism in atherosclerosis.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable