SAB4300601

Anti-MDM2 (Ab-166) antibody produced in rabbit

affinity isolated antibody

• Szinonimák: Anti-HDMX antibody produced in rabbit, Anti-MGC71221 antibody produced in rabbit, Anti-Mdm2 p53 binding protein homolog (mouse) antibody produced in rabbit, Anti-hdm2 antibody produced in rabbit
• MDL-szám: MFCD00282354
• UNSPSC kód: 12352203
• NACRES: NA.41
• konjugátum: unconjugated
• application: IF; IHC (p); WB
• klón: polyclonal
• faj reaktivitás: human
• citations: 3
• technika/technikák: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000

Tulajdonságok

• biológiai forrás: rabbit
• Minőségi szint: 100
• konjugátum: unconjugated
• antitest forma: affinity isolated antibody
• antitest terméktípus: primary antibodies
• klón: polyclonal
• Forma: buffered aqueous solution
• molekulatömeg: ~90 kDa
• faj reaktivitás: human
• koncentráció: 1 mg/mL
• technika/technikák: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• izotípus: IgG
• immunogén szekvencia: (A-I-S-E-T)
• NCBI elérési szám: NP_002383.2
• UniProt elérési szám: Q00987
• kiszállítva: wet ice
• tárolási hőmérséklet: −20°C
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: human ... MDM2(4193)

Leírás

Immunogén

Peptide sequence around aa. 164-168 (A-I-S-E-T), according to the protein MDM2.

Tulajdonságok és előnyök

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Cél megnevezése

This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.

Fizikai forma

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable