Összes fotó(3)
Fontos dokumentumok
S6936
Anti-Sodium Channel, Pan antibody produced in rabbit
affinity isolated antibody, lyophilized powder
Szinonimák:
Anti-SP19
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(3)
About This Item
konjugátum:
unconjugated
application:
IHC (p)
IP
WB CL
IP
WB CL
klón:
polyclonal
faj reaktivitás:
rat
citations:
15
technika/technikák:
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunoprecipitation (IP): suitable
western blot (chemiluminescent): 1:200-1:600
immunoprecipitation (IP): suitable
western blot (chemiluminescent): 1:200-1:600
Javasolt termékek
biológiai forrás
rabbit
Minőségi szint
konjugátum
unconjugated
antitest forma
affinity isolated antibody
antitest terméktípus
primary antibodies
klón
polyclonal
Forma
lyophilized powder
faj reaktivitás
rat
technika/technikák
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunoprecipitation (IP): suitable
western blot (chemiluminescent): 1:200-1:600
UniProt elérési szám
tárolási hőmérséklet
−20°C
célzott transzláció utáni módosítás
unmodified
Géninformáció
rat ... Scn1a(81574)
Általános leírás
Voltage-gated sodium channels (VGSC) are membrane proteins that are usually present in excitable cells. These sodium channels regulate neurological functions such as the generation of action potentials in nerve cells. Alterations in neurological sodium ion channels have been associated with epilepsy, whereas mutations in cardiac sodium channels have been linked to long QT syndrome . Anti-Sodium Channel, Pan antibody is specific for the α subunit of VGSC in rats.
Immunogén
synthetic peptide corresponding to amino acids 1491-1508 of the α subunit of rat type I voltage-gated sodium channel (VGSC, SP19) (with additional C-terminal cysteine). The epitope corresponds to the sequence in the intracellular loop between the III and IV domains of the VGSC α subunit.This epitope is identical in vertebrates, and highly homologous in mollusks and insects.
Alkalmazás
Anti-Sodium Channel, Pan antibody is suitable for use in immunohistochemistry (formalin-fixed, paraffin-embedded sections), immunoprecipitation and chemiluminescent western blot.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Immunohistochemistry (1 paper)
Immunofluorescence (1 paper)
Immunohistochemistry (1 paper)
Fizikai forma
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.
Jogi nyilatkozat
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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javasolt
Figyelmeztetés
Danger
Figyelmeztető mondatok
Óvintézkedésre vonatkozó mondatok
Veszélyességi osztályok
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3
Tárolási osztály kódja
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
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Megan Oliva et al.
Epilepsia, 53(11), 1849-1859 (2012-08-22)
Voltage-gated sodium channels (VGSCs) are integral membrane proteins. They are essential for normal neurologic function and are, currently, the most common recognized cause of genetic epilepsy. This review summarizes the neurobiology of VGSCs, their association with different epilepsy syndromes, and
Margarita Calvo et al.
eLife, 5, e12661-e12661 (2016-04-02)
Neuropathic pain following peripheral nerve injury is associated with hyperexcitability in damaged myelinated sensory axons, which begins to normalise over time. We investigated the composition and distribution of shaker-type-potassium channels (Kv1 channels) within the nodal complex of myelinated axons following
G M Vincent et al.
Cardiology in review, 7(1), 44-55 (1999-06-01)
The inherited long QT syndrome is caused by mutations of at least 5 ion channel genes. Mutations of the cardiac sodium ion channel gene and 3 potassium channel genes have been identified to this time. A genetic locus on chromosome
X Liu et al.
Respiratory physiology & neurobiology, 178(3), 362-369 (2011-03-15)
Experiments in recent years have revealed labile electrophysiological and neurochemical phenotypes in primary afferent neurons exposed to specific stimulus conditions associated with the development of chronic pain. These studies collectively demonstrate that the mechanisms responsible for functional plasticity are primarily
Chunling Chen et al.
The Journal of biological chemistry, 287(46), 39061-39069 (2012-09-21)
Voltage-gated Na(+) channels in the brain are composed of a single pore-forming α subunit, one non-covalently linked β subunit (β1 or β3), and one disulfide-linked β subunit (β2 or β4). The final step in Na(+) channel biosynthesis in central neurons
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