RAB0036
Human Carbonic Anhydrase IX ELISA Kit
for serum, plasma, cell culture supernatant and urine
Szinonimák:
CA9
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(2)
About This Item
UNSPSC kód:
41116158
NACRES:
NA.32
Javasolt termékek
faj reaktivitás
human
kiszerelés
kit of 96 wells (12 strips x 8 wells)
technika/technikák
ELISA: suitable
capture ELISA: suitable
bemenet
sample type plasma
sample type serum
sample type cell culture supernatant(s)
sample type urine
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.2 pg/mL
standard curve range: 0.205-50 pg/mL
észlelési módszer
colorimetric
kiszállítva
wet ice
tárolási hőmérséklet
−20°C
Géninformáció
human ... CA9(768)
Általános leírás
Carbonic anhydrase IX (CA9) belongs to the zinc-containing metalloenzymes family. The protein is encoded by the gene mapped to human chromosome 9p. The encoded protein is localized on cell membrane and is characterized with an N-terminal proteoglycan-like domain (PG), a CA catalytic domain (CA), a transmembrane helical segment and a short intra-cytoplasmic tail. CA9 is expressed at very low levels in normal tissues (mostly in gastrointestinal tract), but it is expressed at high level in various cancer tissues, such as renal, lung, cervical, ovarian, esophageal and breast cancer.
The Human CA-IX (Carbonic Anhydrase IX) ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human CA-IX in serum, plasma, cell culture supernatants and urine.
Immunogén
Recombinant Human CA9
Alkalmazás
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Biokémiai/fiziológiai hatások
Carbonic anhydrase IX (CA9) aids in reversible hydration of carbon dioxide to carbonic acid and bicarbonate. CA9 functions as a promising biomarker for diagnosing clear cell renal cell carcinoma (ccRCC), tumor hypoxia and prostate cancer (PC). In addition to pH control, CA9 also plays a vital role in cell proliferation, adhesion and tumor invasion.
Egyéb megjegyzések
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
Kit Components Also Available Separately
Product No.
Leírás
Biztonsági adatlap
- RABELADBELISA 5X Assay/Sample Diluent Buffer B (Item E1)Biztonsági adatlap
- RABELADCELISA 1X Assay/Sample Diluent Buffer C (Item L)Biztonsági adatlap
- RABSTOP3ELISA Stop Solution (Item I)Biztonsági adatlap
- RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)Biztonsági adatlap
- RABWASH420X Wash Buffer (Item B)Biztonsági adatlap
Figyelmeztetés
Warning
Figyelmeztető mondatok
Óvintézkedésre vonatkozó mondatok
Veszélyességi osztályok
Met. Corr. 1
Tárolási osztály kódja
8A - Combustible corrosive hazardous materials
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Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes.
Hilvo M
The Journal of Biological Chemistry, 283(41), 27799-27809 (2008)
D S Pisetsky et al.
Cytokine, 69(1), 110-115 (2014-07-16)
Anorexia nervosa (AN) is a serious, potentially life-threatening disorder characterized by severe weight loss, dysregulated eating, and often excessive exercise. While psychiatric illnesses such as depression are associated with increased levels of pro-inflammatory mediators, evidence for such disturbances in patients
CA9 as a biomarker in preoperative biopsy of small solid renal masses for diagnosis of clear cell renal cell carcinoma.
Li G
Biomarkers, 22(2), 123-126 (2017)
Chromosome 9p deletions identify an aggressive phenotype of clear cell renal cell carcinoma.
La Rochelle J
Cancer, 116(20), 4696-4702 (2010)
L Covolo et al.
Alimentary pharmacology & therapeutics, 39(3), 322-330 (2013-12-07)
A novel dinucleotide variant TT/∆G (ss469415590) has been associated with hepatitis C virus clearance. To assess the role of the ss469415590 variant, compared with the known IL28B polymorphisms (rs8099917, rs12979860 and rs12980275) for predicting virological response to therapy in chronic
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