P4932

Polymyxin B sulfate salt

powder, non-animal origin, suitable for cell culture, BioReagent

• Szinonimák: Polymixin, Polymixin B, Polymixin B sulfate
• Tapasztalati képlet (Hill-képlet): C₅₅H₉₆N₁₆O₁₃ · 2H₂SO₄
• CAS-szám: 1405-20-5
• Molekulatömeg: 1385.61
• EC-szám: 215-774-7
• MDL-szám: MFCD00131991
• UNSPSC kód: 12352207
• NACRES: NA.76

Tulajdonságok

• Terméknév: Polymyxin B sulfate salt, powder, BioReagent, suitable for cell culture
• termékcsalád: BioReagent
• Minőségi szint: 200
• Forma: powder
• hatékonyság: ≥6,000 USP units per mg
• technika/technikák: cell culture | mammalian: suitable
• antibiotikus hatásspektrum: Gram-negative bacteria
• Hatásmechanizmus: cell membrane | interferes
• tárolási hőmérséklet: 2-8°C
• SMILES string: O=C(C(NC(C(CCN)NC(CCCCC(C)CC)=O)=O)C(C)O)NC(CCN)C(NC(CCNC(C(NC(C(NC(C(CCN)N1)=O)CCN)=O)C(O)C)=O)C(NC(CCN)C(NC(CC2=CC=CC=C2)C(NC(CC(C)C)C1=O)=O)=O)=O)=O.O=S(O)(O)=O
• InChI: 1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)
• Nemzetközi kémiai azonosító kulcs: HNDFYNOVSOOGDU-UHFFFAOYSA-N

Leírás

Általános leírás

Polymyxin B is a member of the polymyxin group of antibiotics, obtained from different strains of Bacillus polymyxa and related species. It contains a cyclic heptapeptide unit and a tripeptide side chain, which is N-acylated by a fatty acyl residue. Polymyxin B sulfate salt is generally used for the treatment of Gram-negative bacterial infections.
Chemical structure: peptide

Alkalmazás

Polymyxin B sulfate salt has been used:

• for the treatment of BAC-1.2F5 murine macrophages as an LPS (lipopolysaccharide) inhibitor
• as positive and negative control during microbicidal concentration (MCC) assay

Biokémiai/fiziológiai hatások

Polymyxin B sulfate has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa. It also has been used in studying multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.

Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides†, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane.

Antimicrobial spectrum: Has bactericidal action on most gram-negative bacilli††, including E. Coli and on most fungi and gram-positive bacteria.

Vigyázat

As supplied, the product should be stored at 2-8°C in the dark. No change was observed in retained samples after three years′ of storage in these conditions. Stock solutions should be sterile filtered and stored at 2-8°C. They are stable at 37°C for 5 days.

Elkészítési megjegyzés

Polymyxin B sulfate is soluble in water at 50 mg/mL, producing a very slightly hazy, colorless to yellow solution. It has only minimal solubility in any organic solvent. For example, it has a solubility of 0.115 mg/mL in ethanol.

Egyéb megjegyzések

1mu,5mu

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

Biztonsági adatok

• Piktogramok: GHS07
• Figyelmeztetés: Warning
• Figyelmeztető mondatok: H302
• Óvintézkedésre vonatkozó mondatok: P264 - P270 - P301 + P312 - P501
• Veszélyességi osztályok: Acute Tox. 4 Oral
• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: dust mask type N95 (US), Eyeshields, Gloves