P4235

Anti-p53 antibody produced in sheep

fractionated antiserum, buffered aqueous solution

• MDL-szám: MFCD00164709
• UNSPSC kód: 12352203
• NACRES: NA.41

Tulajdonságok

• biológiai forrás: sheep
• Minőségi szint: 200
• konjugátum: unconjugated
• antitest forma: fractionated antiserum
• antitest terméktípus: primary antibodies
• klón: polyclonal
• form: buffered aqueous solution
• molekulatömeg: antigen 53 kDa
• faj reaktivitás: rat, mouse, human
• technika/technikák: immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; immunoprecipitation (IP): suitable; western blot: 1-10 μg/mL
• UniProt elérési szám: P04637
• kiszállítva: dry ice
• tárolási hőmérséklet: −20°C
• Géninformáció: human ... TP53(7157) ; mouse ... Trp53(22059) ; rat ... Tp53(24842)

Leírás

Általános leírás

p53 is a tumor suppressor gene expressed in a wide variety of tissues. It is a tetrameric nuclear DNA-binding phosphoprotein. The gene encoding it is localized on human chromosome 17p13.1 and mouse chromosome 11.

Immunogen

GST fusion protein of human p53 corresponding to amino acids 1-393.

Alkalmazás

Monoclonal Anti-p53-Biotin antibody produced in mouse has been used for Western Blotting.

Biokémiai/fiziológiai hatások

Tumor suppressor p53 has the capability to induce cell cycle arrest and has a role in DNA repair, senescence and apoptosis. It binds to Simian vacuolating virus 40 (SV40) T-antigen and human papilloma virus E6 protein. The p53 gene is mutated in various cancers, such as of the breast, ovarian, bladder, colon and lung.

Fizikai forma

Solution in 0.01 M phosphate buffered saline, containing 0.08% sodium azide.

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable