Összes fotó(1)
Fontos dokumentumok
P2318
Anti-Pseudomonas Exotoxin A antibody produced in rabbit
whole antiserum
Szinonimák:
Anti-ETA
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
konjugátum:
unconjugated
application:
DB
ELISA (i)
ELISA (i)
klón:
polyclonal
faj reaktivitás:
(Pseudomonas aeruginosa)
citations:
19
technika/technikák:
dot blot: 1:20,000
indirect ELISA: 1:250,000
indirect ELISA: 1:250,000
Javasolt termékek
biológiai forrás
rabbit
Minőségi szint
konjugátum
unconjugated
antitest forma
whole antiserum
antitest terméktípus
primary antibodies
klón
polyclonal
tartalmaz
15 mM sodium azide
faj reaktivitás
(Pseudomonas aeruginosa)
technika/technikák
dot blot: 1:20,000
indirect ELISA: 1:250,000
kiszállítva
dry ice
tárolási hőmérséklet
−20°C
célzott transzláció utáni módosítás
unmodified
Géninformáció
Pseudomonas aeruginosa PAO1 ... toxA(877850)
Általános leírás
Reacts against Pseudomonas exotoxin A, but shows no reaction against Staphylococcal enterotoxin A, Cholera toxin, and Staphylococcal enterotoxin B. The product has not been tested for neutralization potency against active Pseudomonas exotoxin A.
Immunogén
exotoxin A from Pseudomonas aeruginosa.
Alkalmazás
Anti-Pseudomonas Exotoxin A antibody has been used in in vitro serum stability of fusion toxins and binding of targeted toxins.
Anti-Pseudomonas exotoxin A antibody produced in rabbit has been used:
- in the in vitro analysis of the stability of fusion toxins in serum
- to construct an epidermal growth factor receptor (EGFR)-targeted toxin to study its toxicity on Swiss mouse embryo NIH-3T3 cells transfected with human EGFR
- in the determination of the in vivo half-life of immunotoxins in serum
Biokémiai/fiziológiai hatások
Pseudomonas exotoxin A is secreted by Pseudomonas aeruginosa and has potent cytotoxic effects. Exotoxin A enters the cells by receptor-mediated endocytosis, translocates to the cytoplasm and inhibits protein synthesis by ADP-ribosylating factor 2. Chimeric exotoxin A has applications in gene treatment of various diseases and probable treatment for cancer.
Fizikai forma
This product is supplied as a liquid containing 15 mM sodium azide as preservative.
Tárolás és stabilitás
For continuous use, store at 2-8 °C for up to one month. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.
Jogi nyilatkozat
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Tárolási osztály kódja
10 - Combustible liquids
WGK
nwg
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
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Analitikai tanúsítványok (COA)
Lot/Batch Number
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