P0020

Pristimerin

• Szinonimák: (9b,13a,14b,20a)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26 -trinoroleana-1(10),3,5,7-tertraen-29-oic acid methyl ester, Celastrol methyl ester
• Tapasztalati képlet (Hill-képlet): C₃₀H₄₀O₄
• CAS-szám: 1258-84-0
• Molekulatömeg: 464.64
• MDL-szám: MFCD01711331
• UNSPSC kód: 12352200
• PubChem Substance ID: 329819975
• NACRES: NA.77

Tulajdonságok

• Teszt: ≥98% (HPLC)
• Minőségi szint: 100
• Forma: powder
• tárolási körülmény: protect from light
• szín: orange
• oldhatóság: DMSO: ≥5 mg/mL
• tárolási hőmérséklet: −20°C
• SMILES string: COC(=O)[C@]1(C)CC[C@]2(C)CC[C@]3(C)C4=CC=C5C(C)=C(O)C(=O)C=C5[C@]4(C)CC[C@@]3(C)C2C1
• InChI: 1S/C30H40O4/c1-18-19-8-9-22-28(4,20(19)16-21(31)24(18)32)13-15-30(6)23-17-27(3,25(33)34-7)11-10-26(23,2)12-14-29(22,30)5/h8-9,16,23,32H,10-15,17H2,1-7H3/t23-,26-,27-,28+,29-,30+/m1/s1
• Nemzetközi kémiai azonosító kulcs: JFACETXYABVHFD-WXPPGMDDSA-N

Leírás

Alkalmazás

Pristimerin has been used as an anti-tumor agent to study its effects on conditionally reprogrammed patient-derived lung adenocarcinoma cells (CRLCs). It has also been used as an anti-tumor agent to study its effects on conditionally reprogrammed patient derived-primary hepatocellular carcinoma cells (CRHCs).

Biokémiai/fiziológiai hatások

More active than euphol against MGL, better activity with rat neurons, but less selective relative to similar enzymes.

More active than euphol against MGL, better activity with rat neurons, but less selective relative to similar enzymes. First MGL inhibitor to act reversibly, several others covalently bind to cysteine residues. Other studies involve multiply mylome, pristimerin inhibits NF-κB activation via inhibition of IKK-α or IKK-β. It is the methyl ester of celastrol (C0869).

Pristimerin is a quinone methide triterpenoid found abundantly in Celastraceae and Hippocrateaceae families. It shows anti-inflammatory, anti-malarial, anti-bacterial, and insecticidal properties. Pristimerin exhibits anti-cancer and anti-proliferative activity by affecting vasculogenesis, apoptosis, autophagy, migration, and invasion of tumor cells. It has been studied to exhibit therapeutic effects against leukemia, glioma, breast cancer, prostate cancer, oral cancer, and lung cancer.

Tulajdonságok és előnyök

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable