O7635

Anti-Osteopontin antibody produced in goat

affinity isolated antibody, lyophilized powder

• Szinonimák: Anti-OPN
• MDL-szám: MFCD02263865
• UNSPSC kód: 12352203
• NACRES: NA.41

Tulajdonságok

• biológiai forrás: goat
• Minőségi szint: 200
• konjugátum: unconjugated
• antitest forma: affinity isolated antibody
• antitest terméktípus: primary antibodies
• klón: polyclonal
• Forma: lyophilized powder
• faj reaktivitás: mouse
• technika/technikák: capture ELISA: 0.2-0.8 μg/mL; immunohistochemistry: 5-15 μg/mL using mouse thymus tissue sections; neutralization: 1-3 μg/mL; western blot: 0.1-0.2 μg/mL
• UniProt elérési szám: P10923
• tárolási hőmérséklet: −20°C
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: mouse ... Spp1(20750)

Leírás

Általános leírás

The OPN (osteopontin) gene is mapped to mouse chromosome 5 E5 and codes for secreted phosphoprotein 1 and is mostly expressed in bone tissue.

Immunogén

purified recombinant mouse osteopontin expressed in NSO cells.

Biokémiai/fiziológiai hatások

Osteopontin (OPN) serves as a ligand to a number of integrin receptors which are associated with cell motility, chemotaxis, invasion and cell survival. Upregulation of OPN gene is observed in tumors such as colorectal carcinomas, breast cancer and contributes to its pathogenesis. OPN is associated with obesity by mediating adipocyte inflammation and insulin resistance upon macrophage activation. OPN functions as an effector molecule in extracellular signalling and promotes fibrosis and myocyte growth.

Fizikai forma

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Analízis megjegyzés

Neutralizes the biological activity of recombinant mouse osteopontin using 293 cells.

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable