Ugrás a tartalomra
Merck
Összes fotó(2)

Key Documents

View All Documentation

M6159

Sigma-Aldrich

α2-Macroglobulin from human plasma

BioUltra, ≥98% (SDS-PAGE)

Szinonimák:

α2-M

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(2)

About This Item

CAS-szám:
1631137-21-7
MDL-szám:
MFCD00130472
UNSPSC kód:
12352202
NACRES:
NA.61

biológiai forrás

human plasma

Minőségi szint

200

termékcsalád

BioUltra

Teszt

≥98% (SDS-PAGE)

form

lyophilized powder

molekulatömeg

~720 kDa (four glycoprotein subunits)

összetétel

Protein, 15-30% biuret

technika/technikák

inhibition assay: suitable

oldhatóság

water: soluble 10 mg protein/mL, clear, colorless

UniProt elérési szám

P01023

tárolási hőmérséklet

−20°C

Géninformáció

human ... A2M(2)

Looking for similar products? Látogasson el ide Útmutató a termékösszehasonlításhoz

Alkalmazás

α2-Macroglobulin was used to study impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-β which is an early biomarker for mild cognitive impairment preceding Alzheimer′s disease. It was also used in the control of the classical and the MBL pathway of complement activation.
Inhibits all classes of endoproteases by forming a complex with the protease. When the protease cleaves the macroglobulin "bait" sequence, the macroglobulin rearranges and traps the protease.

Biokémiai/fiziológiai hatások

α2-Macroglobulin (α2M) is a multifunctional protein that is a broad spectrum protease inhibitor. α2M is a large homotetrameric glycoprotein (720 kDa) that is connected by disulfide-linked dimers which non-covalently interact to give the quaternary structure. α2M is found in normal plasma at a concentration of 220-230 mg/dl accounting for 3-5% of the total plasma protein.
α2-Macroglobulin is found abundantly in plasma and interstitial fluids. The protease-α2-M balance plays an important role in mediating inflammatory tissue destruction. Serum levels of α2-M and protease-α2-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis, and other inflammatory diseases, and oxidant inactivation of α2-M may contribute to tissue destruction during inflammation.

Kiszerelés

Package size based on protein content

Fizikai forma

Lyophilized from 0.02 M Tris, 0.13 M glycine, pH 8.0, and 0.08 M trehalose

Analízis megjegyzés

Plasma from each donor has been tested and found negative for antibody to HIV-1/HIV-2, antibody to HCV and HbSAg.

Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 3

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

Már rendelkezik ezzel a termékkel?

Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.

Dokumentumtár megtekintése

Changqi Sun et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 41(1), 241-248 (2022-04-23)
A hallmark of osteoarthritis (OA) is cartilage degeneration, which has been previously correlated with dramatic increases in inflammatory enzymes. Specifically, interleukin-1β (IL-1β) and subsequent upregulation of nuclear factor kappa B (NF-κB) is implicated as an important player in the development
Structural characterization of human alpha2-macroglobulin subunits.
R P Swenson et al.
The Journal of biological chemistry, 254(11), 4452-4456 (1979-06-10)
Osama A Hamad et al.
Journal of immunology (Baltimore, Md. : 1950), 184(5), 2686-2692 (2010-02-09)
It has been reported that complement is activated on the surface of activated platelets, despite the presence of multiple regulators of complement activation. To reinvestigate the mechanisms by which activated platelets bind to complement components, the presence of complement proteins
E M Smergel et al.
Clinical nuclear medicine, 12(5), 349-353 (1987-05-01)
Fourteen patients with slipped capital femoral epiphysis (SCFE) who had high-resolution and magnification bone scintigraphy during treatment were studied. By demonstrating the vascular status of the femoral head and physiologic condition of the growth plate, scintigraphy was found to assist
Wen-Feng Zeng et al.
Scientific reports, 6, 25102-25102 (2016-05-04)
Confident characterization of the microheterogeneity of protein glycosylation through identification of intact glycopeptides remains one of the toughest analytical challenges for glycoproteomics. Recently proposed mass spectrometry (MS)-based methods still have some defects such as lack of the false discovery rate
View All Related Papers

Cikkek

Elastase Function and Importance

Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.

Papain, Cysteine Protease, Properties & Products

Uncover properties and applications of the cysteine protease papain and find inhibitors, substrates, and other papain products.

Papain, cisztein-proteáz, tulajdonságok és termékek

Fedezze fel a cisztein-proteáz papain tulajdonságait és alkalmazásait, és keressen gátlókat, szubsztrátokat és egyéb papaintermékeket.

Tudóscsoportunk valamennyi kutatási területen rendelkezik tapasztalattal, beleértve az élettudományt, az anyagtudományt, a kémiai szintézist, a kromatográfiát, az analitikát és még sok más területet.

Lépjen kapcsolatba a szaktanácsadással