Összes fotó(1)
Fontos dokumentumok
M1508
4-Methylumbelliferone sodium salt
fluorogenic, ≥98% (HPLC), crystalline
Szinonimák:
β-Methylumbelliferone, 7-Hydroxy-4-methylcoumarin
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
Lineáris képlet:
C10H7O3Na
CAS-szám:
Molekulatömeg:
198.15
EC-szám:
MDL-szám:
UNSPSC kód:
12352204
PubChem Substance ID:
NACRES:
NA.32
Javasolt termékek
Terméknév
4-Methylumbelliferone sodium salt, ≥98% (HPLC), crystalline
Minőségi szint
Teszt
≥98% (HPLC)
Forma
crystalline
szín
yellow
oldhatóság
water: 50 mg/mL
SMILES string
[Na+].CC1=CC(=O)Oc2cc([O-])ccc12
InChI
1S/C10H8O3.Na/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9;/h2-5,11H,1H3;/q;+1/p-1
Nemzetközi kémiai azonosító kulcs
JGMQHDNPUCPRQE-UHFFFAOYSA-M
Általános leírás
4-methylumbelliferone (4-MU) is a coumarin derivative.
Alkalmazás
4-Methylumbelliferone sodium salt has been used:
- as a substrate to analyze the enzyme kinetics of its glucuronidation in the human liver
- as a standard to quantify the free 4-methylumbelliferone released as a result of enzyme-substrate action
- in cell survival assay to inhibit hyaluronan (HA) production and to study its effect on chemoresistance in ovarian cancer
Biokémiai/fiziológiai hatások
4-methylumbelliferone (4-MU) serves as a hyaluronan (HA) synthesis blocker. It exhibits anti-inflammatory, anti-fibrogenic, and antitumor properties. 4-MU is used to treat biliary spasms and might also be beneficial in nonalcoholic steatohepatitis (NASH), inflammation, hepatocyte injury, and fibrotic response. 4-MU is known to be glucuronidated by most of the uridine 5ฺ-diphospho-glucuronosyltransferase (UGT) isoforms of the human liver. This makes it a potent probe substrate to examine the overall hepatic UGTs activity.
Tárolási osztály kódja
11 - Combustible Solids
WGK
WGK 3
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Egyéni védőeszköz
Eyeshields, Gloves, type N95 (US)
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