Összes fotó(1)
Fontos dokumentumok
I8273
Anti-Interleukin-2 antibody produced in goat
IgG fraction of antiserum, lyophilized powder
Szinonimák:
Anti-IL-2
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
konjugátum:
unconjugated
application:
Neutral
WB
WB
klón:
polyclonal
faj reaktivitás:
human
citations:
5
technika/technikák:
neutralization: suitable
western blot: 1 μg/mL
western blot: 1 μg/mL
Javasolt termékek
biológiai forrás
goat
Minőségi szint
konjugátum
unconjugated
antitest forma
IgG fraction of antiserum
antitest terméktípus
primary antibodies
klón
polyclonal
Forma
lyophilized powder
faj reaktivitás
human
technika/technikák
neutralization: suitable
western blot: 1 μg/mL
UniProt elérési szám
tárolási hőmérséklet
−20°C
célzott transzláció utáni módosítás
unmodified
Géninformáció
human ... IL2(3558)
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Általános leírás
Interleukin-2 (IL-2) is a cytokine produced by activated T cells in response to antigen stimulation. IL-2 is important for proliferation of lymphocytes, natural killer cells and macrophages and in the differentiation of CD4+ cells into Th1 and Th2 effector cells. The effects of IL-2 are mediated by the signalling activated by its binding to IL-2 receptor (IL-2 R). IL-2 activates key signalling pathways such as MAPK, JAK/STAT as well as PI3K/Akt. Activation of these pathways modulates production of inflammatory cytokines, survival and progression through cell cycle
Monoclonal Anti-Interleukin-2 recognizes human Interleukin-2. It also neutralizes recombinant, mouse IL-2, but requires 30-50 times the antibody concentration required to neutralize human IL-2.
Monoclonal Anti-Interleukin-2 recognizes human Interleukin-2. It also neutralizes recombinant, mouse IL-2, but requires 30-50 times the antibody concentration required to neutralize human IL-2.
Egyediség
The antibody neutralizes the biological activity of recombinant human IL-2.
Immunogén
recombinant human interleukin-2 expressed in Escherichia coli.
Alkalmazás
Anti-interleukin-2 antibody is suitable for IL-2 neutralization assays.
Fizikai forma
Lyophilized from a 0.2 μm filtered solution of phosphate buffered saline containing carbohydrates.
Elkészítési megjegyzés
Purified using protein G.
Jogi nyilatkozat
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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kapcsolódó termék
Product No.
Leírás
Árazás
Tárolási osztály kódja
11 - Combustible Solids
WGK
WGK 1
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Egyéni védőeszköz
Eyeshields, Gloves, type N95 (US)
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Matthew A Williams et al.
Nature, 441(7095), 890-893 (2006-06-17)
Although interleukin-2 (IL-2) was initially characterized as the primary T-cell growth factor following in vitro activation, less is known about its role in shaping T-cell responses to acute infections in vivo. The use of IL-2- or IL-2-receptor-deficient mice is problematic
B H Nelson et al.
Advances in immunology, 70, 1-81 (1998-10-02)
Studies of the biology of the IL-2 receptor have played a major part in establishing several of the fundamental principles that govern our current understanding of immunology. Chief among these is the contribution made by lymphokines to regulation of the
Katrina K Hoyer et al.
Immunological reviews, 226, 19-28 (2009-01-24)
Interleukin-2 (IL-2) has multiple, sometimes opposing, functions during an inflammatory response. It is a potent inducer of T-cell proliferation and T-helper 1 (Th1) and Th2 effector T-cell differentiation and provides T cells with a long-lasting competitive advantage resulting in the
Arian Laurence et al.
Immunity, 26(3), 371-381 (2007-03-17)
Recent work has identified a new subset of effector T cells that produces interleukin (IL)-17 known as T helper 17 (Th17) cells, which is involved in the pathophysiology of inflammatory diseases and is thought to be developmentally related to regulatory
Hans Dooms et al.
Journal of immunology (Baltimore, Md. : 1950), 172(10), 5973-5979 (2004-05-07)
The acquisition of long-term survival potential by activated T lymphocytes is essential to ensure the successful development of a memory population in the competitive environment of the lymphoid system. The factors that grant competitiveness for survival to primed T cells
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