Összes fotó(1)
Fontos dokumentumok
H7791
IL-17A human
HumanKine®, recombinant, Xeno-free, >95% (SDS-PAGE), suitable for cell culture
Szinonimák:
CTLA-8, IL-17
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
Javasolt termékek
product name
Interleukin-17A human, IL-17A, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
biológiai forrás
human
Minőségi szint
rekombináns
expressed in HEK 293 cells
Teszt
≥95% (SDS-PAGE)
form
lyophilized powder
hatékonyság
≤2 ng/mL EC50
minőség
endotoxin tested
molekulatömeg
dimer 30-35 kDa (glycosylated)
kiszerelés
pkg of 10 μg
technika/technikák
cell culture | mammalian: suitable
szennyeződések
≤1 EU/μg
UniProt elérési szám
tárolási hőmérséklet
−20°C
Géninformáció
human ... IL17A(3605)
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Biokémiai/fiziológiai hatások
IL-17, initially known as CTLA-8, is a T cell-expressed polypeptide that appears to be involved in the regulation of the hematopoietic system. IL-17 has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis.
IL-17A belongs to the IL-17 family and is produced by Th17 cells, a subset of T helper cells. Interleukin 17 (IL-17), initially known as CTLA-8, is a T cell expressed polypeptide that appears to be involved in the regulation of the hematopoietic system. IL-17 has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis. IL-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines, upregulates production of growth factors that promote angiogenesis, and enhances expression of adhesion molecules in fibroblasts.
Fizikai forma
Lyophilized from a 0.2 μm filtered solution of 10 mM Tris-HCl pH 7.4+ 250 mM NaCl
Elkészítési megjegyzés
HumanKine Interleukin-17A (IL-17A), expressed in human HEK 293 cells, is a glycosylated homodimer with an apparent molecular mass of 30-35 kDa due to glycosylation. Production in human 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.
Analízis megjegyzés
The specific activity was determined by the dose-dependent induction of IL-6 secretion from NDHF adult fibroblasts.
Jogi információk
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
Tárolási osztály kódja
11 - Combustible Solids
WGK
WGK 3
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
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