H0513

Heptakis(2,6-di-O-methyl)-β-cyclodextrin

• Szinonimák: DM-β-CD, DM‐β‐CyD, heptakis-(2,6-O-Dimethyl)-β-cyclodextrin, 2,6-Di-O-methyl-β-cyclodextrin, Dimethyl β-cyclodextrin
• Tapasztalati képlet (Hill-képlet): C₅₆H₉₈O₃₅
• CAS-szám: 51166-71-3
• Molekulatömeg: 1331.36
• Beilstein: 1679144
• MDL-szám: MFCD00011616
• UNSPSC kód: 12352005
• PubChem Substance ID: 24895404
• NACRES: NA.22

Tulajdonságok

• biológiai forrás: synthetic
• Minőségi szint: 200
• Forma: powder
• SMILES string: COC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](OC)[C@H](O[C@@H]3COC)O[C@H]4[C@H](O)[C@@H](OC)[C@H](O[C@@H]4COC)O[C@H]5[C@H](O)[C@@H](OC)[C@H](O[C@@H]5COC)O[C@H]6[C@H](O)[C@@H](OC)[C@H](O[C@@H]6COC)O[C@H]7[C@H](O)[C@@H](OC)[C@H](O[C@@H]7COC)O[C@H]8[C@H](O)[C@@H](OC)[C@H](O[C@@H]8COC)O[C@H]1[C@H](O)[C@H]2OC
• InChI: 1S/C56H98O35/c1-64-15-22-36-29(57)43(71-8)50(78-22)86-37-23(16-65-2)80-52(45(73-10)30(37)58)88-39-25(18-67-4)82-54(47(75-12)32(39)60)90-41-27(20-69-6)84-56(49(77-14)34(41)62)91-42-28(21-70-7)83-55(48(76-13)35(42)63)89-40-26(19-68-5)81-53(46(74-11)33(40)61)87-38-24(17-66-3)79-51(85-36)44(72-9)31(38)59/h22-63H,15-21H2,1-14H3/t22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-/m1/s1
• Nemzetközi kémiai azonosító kulcs: QGKBSGBYSPTPKJ-UZMKXNTCSA-N

Leírás

Általános leírás

Heptakis(2,6-di-O-methyl)-β-cyclodextrin is a hydrophilic derivative of cyclodextrin that possesses the ability to effectively dissolve lipophilic drugs like steroid hormones, vitamins A, E, and K, etc. It can be utilized to increase the dissolution and bioavailability of weakly water-soluble pharmaceutical compounds.

Alkalmazás

Heptakis(2,6-di-O-methyl)-β-cyclodextrin may be used:

• To measure the equilibrium constant of its complexes with various enantiomeric pairs of chiral nitroxides by electron paramagnetic resonance (EPR) spectroscopy.
• To study the crystal structure of its complex with n-butyl acrylate and isobornyl acrylate using X-ray diffraction (XRD).
• As a chiral selector to resolve amphetamine related drugs by capillary zone electrophoresis.

Reactant involved in:

• Physicochemical studies of inclusion complexes
• Probing diffusion and single molecule interactions with reconstituted membrane proteins
• Interactions with micelles causing micellar rupture
• Studying cellular transport, used as a cell penetration enhancer
• Physicochemical and biopharmaceutical improvement of drugs particularly with solubilization and stability
• Interactions with cholesterol

Minőség

Impurities are over-methylated homologs, primarily hexakis(2,6-di-O-methyl)-(2,3,6-tri-O-methyl)-β-cyclodextrin.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)