Összes fotó(1)
Fontos dokumentumok
G8296
GRK5, active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Szinonimák:
GPRK5
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
UNSPSC kód:
12352200
NACRES:
NA.32
Javasolt termékek
rekombináns
expressed in baculovirus infected Sf9 cells
Minőségi szint
termékcsalád
PRECISIO® Kinase
Teszt
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specifikus aktivitás
32-44 nmol/min·mg
molekulatömeg
~95 kDa
UniProt elérési szám
kiszállítva
dry ice
tárolási hőmérséklet
−70°C
Géninformáció
human ... GRK5(2869)
Általános leírás
GRK5 (G protein-coupled receptor kinase 5) belongs to the G-protein coupled receptor kinase family, and shows major expression in normal human heart. This protein contains a nuclear localization sequence and hence localizes in nucleus.
Biokémiai/fiziológiai hatások
GRK5 (G protein-coupled receptor kinase 5) controls the functions of catecholamines, which bind and activate β-adrenergic receptors, and have cardiac inotropic and chronotropic actions. It is responsible for the uncoupling from G protein by facilitating β1-adrenergic receptor phosphorylation and β-arrestin recruitment. This protein plays a key role in growth and metastasis in prostate cancer, where it phosphorylates moesin.† A genome-wide association study (GWAS) has shown that rs10886471 variant in GRK5 gene is linked with susceptibility to type 2 diabetes mellitus (T2DM).
Fizikai forma
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Jogi információk
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Tárolási osztály kódja
10 - Combustible liquids
WGK
WGK 1
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Egyéni védőeszköz
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
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Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.
Prabir Kumar Chakraborty et al.
Cancer research, 74(13), 3489-3500 (2014-04-24)
G protein-coupled receptor kinases (GRK) regulate diverse cellular functions ranging from metabolism to growth and locomotion. Here, we report an important contributory role for GRK5 in human prostate cancer. Inhibition of GRK5 kinase activity attenuated the migration and invasion of
Zhenfang Xia et al.
PloS one, 9(3), e90597-e90597 (2014-03-07)
A genome-wide association study had showed G-protein-coupled receptor kinase 5 (GRK5) rs10886471 was related to the risk of type 2 diabetes mellitus (T2DM) through upregulated GRK5 mRNA expression. Rs10886471 is located in the intron region of GRK5. However, the mechanism
Miklos D Kertai et al.
Circulation. Cardiovascular genetics, 7(5), 625-633 (2014-07-23)
We hypothesized that genetic variations in the adrenergic signaling pathway and cytochrome P450 2D6 enzyme are associated with new-onset atrial fibrillation (AF) in patients who underwent coronary artery bypass grafting and were treated with perioperative β-blockers (BBs). Two cohorts of
P Kunapuli et al.
Proceedings of the National Academy of Sciences of the United States of America, 90(12), 5588-5592 (1993-06-15)
Guanine nucleotide binding protein (G-protein)-coupled receptor kinases (GRKs) specifically phosphorylate the agonist-occupied form of G-protein-coupled receptors such as the beta 2-adrenergic receptor and rhodopsin. The best characterized members of this family include the beta-adrenergic receptor kinase (beta ARK) and rhodopsin
Jie Fan et al.
Nature medicine, 9(3), 315-321 (2003-02-20)
Polymorphonuclear leukocytes (PMNs) are critical effector cells of the innate immune system that protect the host by migrating to inflammatory sites and killing pathogenic microbes. We addressed the role of chemokine receptor desensitization induced by G-protein-coupled receptor kinases (GRKs) in
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