Ugrás a tartalomra
Merck

F3393

Sigma-Aldrich

Anti-Fibroblast Growth Factor-Basic (1-24) antibody produced in rabbit

fractionated antiserum, lyophilized powder

Szinonimák:

Anti-FGF2, Anti-bFGF

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez


About This Item

MDL-szám:
UNSPSC kód:
12352203
NACRES:
NA.41
konjugátum:
unconjugated
application:
ELISA (i)
IHC (p)
WB
klón:
polyclonal
faj reaktivitás:
human, bovine, rat
citations:
14
technika/technikák:
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
western blot: 1:1,000

biológiai forrás

rabbit

Minőségi szint

konjugátum

unconjugated

antitest forma

fractionated antiserum

antitest terméktípus

primary antibodies

klón

polyclonal

Forma

lyophilized powder

faj reaktivitás

human, bovine, rat

technika/technikák

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
western blot: 1:1,000

szennyeződések

endotoxin, tested

UniProt elérési szám

alkalmazás(ok)

research pathology

tárolási hőmérséklet

2-8°C

célzott transzláció utáni módosítás

unmodified

Géninformáció

bovine ... FGF2(281161)
human ... FGF2(2247)
rat ... Fgf2(54250)

Általános leírás

Fibroblast growth factor-basic (FGFb), also known as NUDT6 (nudix (nucleoside diphosphate linked moiety X)-type motif 6) is encoded by the gene mapped to human chromosome 4q28.1. The FGFb gene spanning 34271 bp on genomic DNA contains 16 exons and six introns. FGFb RNA transcripts are expressed in various human tissues including liver, thymus, spleen, peripheral blood leukocytes, heart skeletal muscle, testis, colon and kidney.

Immunogén

synthetic peptide sequence corresponding to bovine FGF2 (1-24).

Alkalmazás

Anti-Fibroblast Growth Factor-Basic (1-24) antibody produced in rabbit has been used in:
  • immunohistochemistry
  • immunostaining
  • immunoblotting

Biokémiai/fiziológiai hatások

Fibroblast Growth Factor Basic (also known as bFGF) is a pleotropic cytokine that that is a potent mitogenic factor. On binding to its cognate receptor tyrosine kinase, FGFR, bFGF is capable of activation of pathways such as MAPK and PI3K and produce cellular effects in varied cell types. Fibroblast Growth Factor-basic is reported to induce proliferation of fibroblasts, differentiation, wound healing and regeneration, limb formation, tissue remodeling and angiogenesis.

Fizikai forma

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Analízis megjegyzés

Bioactivity: Anti-Fibroblast Growth Factor-Basic (1-24) caused a dose-dependent decrease in the mitogenic activity of FGF-Basic such that a final dilution of 1:50 neutralized the bioactivity of 1 unit of FGF Basic.

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 3

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

Egyéni védőeszköz

Eyeshields, Gloves, type N95 (US)


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Analitikai tanúsítványok (COA)

Lot/Batch Number

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Correlation of astrocyte elevated gene-1, basic-fibroblast growth factor, beta-catenin, Ki-67, tumor necrosis factor-alfa with prognostic parameters in ductal carcinomas and ductal intraepithelial neoplasms
Erdem H, et al.
Nigerian Journal of Clinical Practice, 18(5), 638-643 (2015)
Effect of human umbilical cord blood mesenchymal stem cells administered by intravenous or intravitreal routes on cryo-induced retinal injury
Mohamed EM, et al.
IUBMB Life, 69(3), 188-201 (2017)
B G Condron
Neuron, 24(3), 531-540 (1999-12-14)
In the grasshopper CNS, serotonergic growth cones cross the midline early in development and initiate expression of serotonin uptake activity, or SERT. To test if the midline contains an activity that induces SERT, cuts were made that separated serotonergic cell
Qian Liu et al.
Experimental and therapeutic medicine, 23(3), 216-216 (2022-02-08)
Hypertension is associated with bladder symptoms. The present study investigated whether an angiotensin receptor blocker could improve the symptoms and pathological changes associated with a neurogenic bladder (NB). A Sprague-Dawley rat model of NB was constructed. Rats in the sham
Joost F M Lensen et al.
Journal of the American Society of Nephrology : JASN, 16(5), 1279-1288 (2005-03-25)
Glycosaminoglycans (GAG) play an important role in renal homeostasis. They are strongly negatively charged polysaccharides that bind and modulate a myriad of proteins, including growth factors, cytokines, and enzymes. With the aid of specific phage display-derived antibodies, the distribution of

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