D9696

Dronedarone hydrochloride

≥98% (HPLC)

• Szinonimák: N-{2-Butyl-3-[4-(3-dibutylaminopropoxy)benzoyl]benzofuran-5-yl}methanesulfonamide hydrochloride, Multaq, SR-33589B
• Tapasztalati képlet (Hill-képlet): C₃₁H₄₄N₂O₅S · HCl
• CAS-szám: 141625-93-6
• Molekulatömeg: 593.22
• MDL-szám: MFCD00914940
• UNSPSC kód: 12352200
• PubChem Substance ID: 329798909
• NACRES: NA.77

Tulajdonságok

• Minőségi szint: 100
• Teszt: ≥98% (HPLC)
• form: powder
• tárolási körülmény: desiccated
• szín: white to off-white
• oldhatóság: DMSO: 15 mg/mL, clear
• kezdeményező: Sanofi Aventis
• tárolási hőmérséklet: 2-8°C
• SMILES string: Cl.CCCCN(CCCC)CCCOc1ccc(cc1)C(=O)c2c(CCCC)oc3ccc(NS(C)(=O)=O)cc23
• InChI: 1S/C31H44N2O5S.ClH/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3;/h13-18,23,32H,5-12,19-22H2,1-4H3;1H
• Nemzetközi kémiai azonosító kulcs: DWKVCQXJYURSIQ-UHFFFAOYSA-N
• Géninformáció: human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779) , HCN4(10021) , KCNJ2(3759) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

Leírás

Alkalmazás

Dronedarone hydrochloride has been used as an anti-arrhythmic drug to assess its impact in P19C5 embryoid bodies (EBs). It has also been used to determine its antiviral potency.

Biokémiai/fiziológiai hatások

Dronedarone is a Class III antiarrhythmic and a multi-channel blocker for atrial fibrillation. It blocks potassium, sodium, and calcium channels and also exhibits antiadrenergic properties.

Dronedarone is a synthetic derivative of amiodarone, which belongs to the class of benzofurane anti-arrhythmic compounds. It might moderately block cytochrome P450 3A4 (CYP3A4) activity. Dronedarone is used to treat atrial flutter.

Tulajdonságok és előnyök

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable