B4272

Bombesin acetate salt hydrate

≥97% (HPLC)

• Szinonimák: pGlu-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH₂
• Tapasztalati képlet (Hill-képlet): C₇₁H₁₁₀N₂₄O₁₈S · xC₂H₄O₂ · yH₂O
• Molekulatömeg: 1619.85 (anhydrous free base basis)
• Beilstein: 9611365
• MDL-szám: MFCD00167514
• UNSPSC kód: 12352209
• PubChem Substance ID: 24891763
• NACRES: NA.32

Tulajdonságok

• Minőségi szint: 200
• Teszt: ≥97% (HPLC)
• Forma: powder
• tárolási hőmérséklet: −20°C
• SMILES string: CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]4CCC(=O)N4)C(C)C)C(N)=O
• InChI: 1S/C71H110N24O18S/c1-34(2)24-47(92-62(105)43(14-11-22-79-71(76)77)89-64(107)45(15-18-52(72)96)90-63(106)44-17-20-55(99)85-44)61(104)81-31-56(100)87-51(28-54(74)98)69(112)91-46(16-19-53(73)97)65(108)94-49(26-38-29-80-41-13-10-9-12-40(38)41)66(109)84-37(7)60(103)95-58(36(5)6)70(113)82-32-57(101)86-50(27-39-30-78-33-83-39)68(111)93-48(25-35(3)4)67(110)88-42(59(75)102)21-23-114-8/h9-10,12-13,29-30,33-37,42-51,58,80H,11,14-28,31-32H2,1-8H3,(H2,72,96)(H2,73,97)(H2,74,98)(H2,75,102)(H,78,83)(H,81,104)(H,82,113)(H,84,109)(H,85,99)(H,86,101)(H,87,100)(H,88,110)(H,89,107)(H,90,106)(H,91,112)(H,92,105)(H,93,111)(H,94,108)(H,95,103)(H4,76,77,79)/t37-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,58-/m0/s1
• Nemzetközi kémiai azonosító kulcs: QXZBMSIDSOZZHK-DOPDSADYSA-N
• Géninformáció: human ... GRPR(2925)

Leírás

Amino Acid Sequence

Glp-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2

Általános leírás

Gastrin releasing peptide receptor (GRP-R) belongs to the G protein-coupled receptors (GPCR) family.[1] The gene for the gastrin‐releasing peptide receptor is located on the short arm of human X chromosome.[2]

Alkalmazás

Bombesin acetate salt hydrate has been used in immunohistochemical methods[3] and food intake measurements.[4]

Biokémiai/fiziológiai hatások

Bombesin/gastrin releasing peptide (BN/GRP) serves as an autocrine growth factor in small cell lung cancer (SCLC).[5] Overexpression of gastrin releasing peptide receptor (GRP-R) is associated with neuroblastoma tumor aggressiveness. GRP-R modulates the important enzymes, that participates in glucose metabolism.[1] Bombesin, a pulmonary growth factor helps to satisfy the conditions for autocrine stimulation.[5]

Tetradecapeptide originally isolated from the skin of the frog Bombina bombina. Bombesin acts at specific brain nuclei to inhibit food intake. It also increases blood glucose levels.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type N95 (US)