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A6150

Sigma-Aldrich

α1-Antitrypsin from human plasma

salt-free, lyophilized powder

Szinonimák:

α1-Proteinase inhibitor

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(2)

About This Item

CAS-szám:
9041-92-3
EC-szám:
232-924-7
MDL-szám:
MFCD00130469
UNSPSC kód:
12352202
NACRES:
NA.77

biológiai forrás

human plasma

Minőségi szint

200

Forma

salt-free, lyophilized powder

koncentráció

≥60% (biuret)

technika/technikák

inhibition assay: suitable

UniProt elérési szám

P01009
P08246

tárolási hőmérséklet

2-8°C

Géninformáció

human ... ELA2(1991) , ELANE(1991) , SERPINA1(5265)

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Biokémiai/fiziológiai hatások

Serine protease inhibitor; inhibits trypsin, chymotrypsin and pancreatic and granulocytic elastase, and acrosin. Effective concentration equimolar with proteinase.The effects of hereditary α1-antitrypsin deficiency and certain autoimmune states result from uncontrolled proteolysis in vivo. Direct α1-antitrypsin replacement therapy has shown promise in animal models of Type 1 diabetes.
≤10 mg will inhibit 1.0 mg of trypsin with activity of 10,000 BAEE units per mg protein. ≤10 mg will inhibit approx. 1.0 mg of ·α-chymotrypsin with activity of 40-50 BTEE units per mg protein.

Vigyázat

Aqueous stock solutions containing 0.01% NaN3 are stable for several months. Solutions can be stored at −80 °C, but should not be refrozen. Unstable below pH 5.5. Inactivated by some non-serine proteinases and by oxidation of active site methionine residue.

Elkészítési megjegyzés

Chromatographically prepared and partially purified.

Jogi nyilatkozat

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 3

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

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Analitikai tanúsítványok (COA)

Lot/Batch Number
0000397950
0000397951
0000397952
0000362953
0000397950

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[Figure: see text].
Kathirvel Alagesan et al.
Analytical and bioanalytical chemistry, 409(2), 529-538 (2016-12-03)
Glycopeptide enrichment is a crucial step in glycoproteomics for which hydrophilic interaction chromatography (HILIC) has extensively been applied due to its low bias towards different glycan types. A systematic evaluation of applicable HILIC mobile phases on glycopeptide enrichment efficiency and
Cynthia L Bristow et al.
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Leslie W Chan et al.
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Cikkek

Elastase Function and Importance

Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.

Chymotrypsin

Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.

Tudóscsoportunk valamennyi kutatási területen rendelkezik tapasztalattal, beleértve az élettudományt, az anyagtudományt, a kémiai szintézist, a kromatográfiát, az analitikát és még sok más területet.

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