17794

Isorhamnetin

≥95.0% (HPLC)

• Szinonimák: 3′-Methoxy-3,4′,5,7-tetrahydroxyflavone, 3′-Methylquercetin, 3,4′,5,7-Tetrahydroxy 3′-methoxyflavone, Isorhamnetol, Quercetin 3′-methyl ether
• Tapasztalati képlet (Hill-képlet): C₁₆H₁₂O₇
• CAS-szám: 480-19-3
• Molekulatömeg: 316.26
• Beilstein: 44723
• EC-szám: 207-545-5
• MDL-szám: MFCD00017310
• UNSPSC kód: 12352205
• PubChem Substance ID: 57647674
• NACRES: NA.47

Tulajdonságok

• Minőségi szint: 100
• Teszt: ≥95.0% (HPLC)
• alkalmazás(ok): metabolomics; vitamins, nutraceuticals, and natural products
• SMILES string: COc1cc(ccc1O)C2=C(O)C(=O)c3c(O)cc(O)cc3O2
• InChI: 1S/C16H12O7/c1-22-11-4-7(2-3-9(11)18)16-15(21)14(20)13-10(19)5-8(17)6-12(13)23-16/h2-6,17-19,21H,1H3
• Nemzetközi kémiai azonosító kulcs: IZQSVPBOUDKVDZ-UHFFFAOYSA-N

Leírás

Általános leírás

Isorhamnetin is an O-methylated flavonol found in fruits, plants, and medicinal herbs. It is a metabolite of quercetin.

Alkalmazás

Isorhamnetin (IRN) has been used:

• as a neuroprotective agent to test its effect on scopolamine-induced cortico-hippocampal learning and memory deficiency in mice
• as a reference standard in quadrupole time-of-flight mass spectrometry (QTOF MS) to analyze and quantify the phenolic compounds present in honey extract
• as a reference standard to determine the phenolic profile of Artemisia species using Reversed-phase high-performance liquid chromatography with diode array detection and electrospray ionization mass spectrometry (RP-HPLC-DAD-ESI-TQ-MS/MS)

Biokémiai/fiziológiai hatások

Isorhamnetin exerts antioxidant, anti-inflammatory, anti-cancer, anti-bacterial, and anti-viral effects. It has shown to be a potential neuroprotective agent by inhibiting neurodegeneration in the hippocampus under Diabetes mellitus (DM) conditions. Isorhamnetin at low levels may serve as an anti-diabetic agent by promoting glucose uptake in skeletal muscle cells and maintaining glucose homeostasis in hyperglycemic conditions. It regulates cell signaling pathways such as Nuclear factor kappa B (NF-κB), phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT), mitogen-activated protein kinase (MAPK) etc. Isorhamnetin elicits protective and therapeutic effects on atherosclerosis and cardiovascular diseases.

Isorhamnetin inhibits adipogenesis by interfering with differentiation of adipose stem cells, by a mechanism involving stabilization of β-catenin and up-regulating the Wnt signaling pathway.

Kiszerelés

Bottomless glass bottle. Contents are inside inserted fused cone.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable
• Egyéni védőeszköz: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges