BP253

Miconazole nitrate

British Pharmacopoeia (BP) Reference Standard

• Szinonimák: (±)-Miconazole nitrate salt, 1-(2,4-Dichloro-β-[(2,4-dichlorobenzyl)oxy]phenethyl)imidazole
• Tapasztalati képlet (Hill-képlet): C₁₈H₁₄Cl₄N₂O · HNO₃
• CAS-szám: 22832-87-7
• Molekulatömeg: 479.14
• EC-szám: 245-256-6
• MDL-szám: MFCD00058161
• UNSPSC kód: 41116107
• NACRES: NA.24

Tulajdonságok

• grade: pharmaceutical primary standard
• API-család: miconazole
• Forma: solid
• eltarthatósági idő: limited shelf life, expiry date on the label
• gyártó/kereskedő neve: BP
• alkalmazás(ok): pharmaceutical; pharmaceutical small molecule
• Formátum: neat
• tárolási hőmérséklet: 2-8°C
• SMILES string: ClC1=CC(Cl)=CC=C1C(OCC2=CC=C(Cl)C=C2Cl)CN3C=CN=C3.[O-][N+](O)=O
• InChI: 1S/C18H14Cl4N2O.HNO3/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11,18H,9-10H2;(H,2,3,4)
• Nemzetközi kémiai azonosító kulcs: MCCACAIVAXEFAL-UHFFFAOYSA-N

Leírás

Általános leírás

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Alkalmazás

Miconazole nitrate BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:

Miconazole and Hydrocortisone Acetate Cream

Miconazole and Hydrocortisone Cream

Miconazole and Hydrocortisone Ointment

Miconazole Eye Drops

Miconazole Oromucosal Gel

Miconazole Cream

Biokémiai/fiziológiai hatások

Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for ergosterol biosynthesis. The inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with phospholipids in the cell membrane, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and interfere with triglyceride and phospholipid biosynthesis.

Kiszerelés

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

Egyéb megjegyzések

Sales restrictions may apply.

Biztonsági adatok

• Piktogramok: GHS07
• Figyelmeztetés: Warning
• Figyelmeztető mondatok: H302,H317
• Óvintézkedésre vonatkozó mondatok: P280 - P301 + P312 + P330
• Veszélyességi osztályok: Acute Tox. 4 Oral - Skin Sens. 1
• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable