MABS65
Anti-Insulin Receptor Antibody, beta subunit, clone CT-3
clone CT-3, from mouse
Szinonimák:
CD220 antigen, insulin receptor
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(3)
About This Item
UNSPSC kód:
12352203
eCl@ss:
32160702
NACRES:
NA.41
klón:
CT-3, monoclonal
application:
IHC
WB
WB
faj reaktivitás:
mouse, rat (demonstrated by independent lab), human
technika/technikák:
immunohistochemistry: suitable
western blot: suitable
western blot: suitable
citations:
7
Javasolt termékek
biológiai forrás
mouse
Minőségi szint
antitest forma
purified antibody
antitest terméktípus
primary antibodies
klón
CT-3, monoclonal
faj reaktivitás
mouse, rat (demonstrated by independent lab), human
technika/technikák
immunohistochemistry: suitable
western blot: suitable
izotípus
IgG1κ
NCBI elérési szám
UniProt elérési szám
kiszállítva
wet ice
célzott transzláció utáni módosítás
unmodified
Géninformáció
human ... INSR(3643)
mouse ... Insr(16337)
rat ... Insr(24954)
Általános leírás
The insulin receptor is a tyrosine kinase receptor that when bound to insulin, initiates multiple signal transduction pathways, including JNK, PI 3-kinase, Akt and PKC. Pharmacological intervention of these Insulin R-dependent pathways is of great interest for the treatment of insulin resistance, obesity and diabetes. The Insulin Receptor (IR) is synthesized as a single polypeptide, which is subsequently cleaved to generate an extracellular α-chain and a transmembrane and intracellular β-chain, tethered together by disulfide bonds. The β-chain has multiple tyrosine phosphorylation sites, including three autophosphorylation sites at its activation loop. The overall structure of the IR is highly homologous to the IGF-I Receptor, except in their c-termini, where the two proteins diverge somewhat. The IR signals primarily by phosphorylating the Insulin Receptor Substrate (IRS) family of proteins, which creates docking sites for SH2-domain containing proteins. Insulin signaling is highly dependent on the PI3 Kinase pathway and Akt, which appear to mediate the functions of insulin.
Egyediség
This antibody recognizes the C-terminus of human Insulin Receptor, beta subunit.
Immunogén
Epitope: C-terminus
Recombinant protein corresponding to the C-terminus of human Insulin Receptor, beta subunit.
Alkalmazás
Detect Insulin Receptor using this Anti-Insulin Receptor Antibody, beta subunit, clone CT-3 validated for use in WB, IH.
Research Category
Metabolism
Metabolism
Research Sub Category
Insulin/Energy Signaling
Insulin/Energy Signaling
Minőség
Evaluated by Western Blot in mouse brain tissue lysate.
Western Blot Analysis: 0.5 µg/ml of this antibody detected Insulin receptor beta subunit on 10 µg of mouse brain tissue lysate.
Western Blot Analysis: 0.5 µg/ml of this antibody detected Insulin receptor beta subunit on 10 µg of mouse brain tissue lysate.
Cél megnevezése
95 kDa
Fizikai forma
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Tárolás és stabilitás
Stable for 1 year at 2-8°C from date of receipt.
Analízis megjegyzés
Control
Mouse brain tissue lysate
Mouse brain tissue lysate
Egyéb megjegyzések
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Jogi nyilatkozat
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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javasolt
Tárolási osztály kódja
12 - Non Combustible Liquids
WGK
WGK 1
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
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Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.
Marcello Casertano et al.
Pharmaceuticals (Basel, Switzerland), 15(3) (2022-03-27)
Diabetes mellitus (DM) represents a complex and multifactorial disease that causes metabolic disorders with acute and long-term serious complications. The onset of DM, with over 90% of cases of diabetes classified as type 2, implies several metabolic dysfunctions leading to
Massimo Genovese et al.
European journal of nutrition, 61(4), 1905-1918 (2022-01-24)
The impact of tea constituents on the insulin-signaling pathway as well as their antidiabetic activity are still debated questions. Previous studies suggested that some tea components act as Protein Tyrosine Phosphatase 1B (PTP1B) inhibitors. However, their nature and mechanism of
Massimo Genovese et al.
Marine drugs, 19(10) (2021-10-23)
An in-depth study on the inhibitory mechanism on protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AR) enzymes, including analysis of the insulin signalling pathway, of phosphoeleganin, a marine-derived phosphorylated polyketide, was achieved. Phosphoeleganin was demonstrated to inhibit both enzymes
Junhee Park et al.
Nature communications, 13(1), 5594-5594 (2022-09-24)
Insulin receptor (IR) signaling defects cause a variety of metabolic diseases including diabetes. Moreover, inherited mutations of the IR cause severe insulin resistance, leading to early morbidity and mortality with limited therapeutic options. A previously reported selective IR agonist without
Rosanna Maccari et al.
European journal of medicinal chemistry, 252, 115270-115270 (2023-03-20)
Type 2 diabetes mellitus (T2DM) is a serious chronic disease with an alarmingly growing worldwide prevalence. Current treatment of T2DM mainly relies on drug combinations in order to control blood glucose levels and consequently prevent the onset of hyperglycaemia-related complications.
Tudóscsoportunk valamennyi kutatási területen rendelkezik tapasztalattal, beleértve az élettudományt, az anyagtudományt, a kémiai szintézist, a kromatográfiát, az analitikát és még sok más területet.
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