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Merck
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FCMAB317PE

Sigma-Aldrich

Milli-Mark® Anti-NeuN-PE Antibody, clone A60

clone A60, Milli-Mark®, from mouse

Szinonimák:

Neuron-Specific Nuclear Protein, Neuna60, A60

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez


About This Item

UNSPSC kód:
12352203
eCl@ss:
32160702
NACRES:
NA.41
konjugátum:
PE
application:
FACS
klón:
A60, monoclonal
faj reaktivitás:
human
citations:
35
technika/technikák:
flow cytometry: suitable

biológiai forrás

mouse

Minőségi szint

konjugátum

PE

antitest forma

purified immunoglobulin

antitest terméktípus

primary antibodies

klón

A60, monoclonal

faj reaktivitás

human

gyártó/kereskedő neve

Milli-Mark®

technika/technikák

flow cytometry: suitable

izotípus

IgG1

kiszállítva

wet ice

célzott transzláció utáni módosítás

unmodified

Géninformáció

human ... RBFOX3(146713)

Related Categories

Általános leírás

NeuN antibody (NEUronal Nuclei; clone A60) specifically recognizes the DNA-binding, neuron-specific protein NeuN, which is present in most CNS and PNS neuronal cell types of all vertebrates tested. NeuN protein distributions are apparently restricted to neuronal nuclei, perikarya and some proximal neuronal processes in both fetal and adult brain although, some neurons fail to be recognized by NeuN at all ages: INL retinal cells, Cajal-Retzius cells, Purkinje cells, inferior olivary and dentate nucleus neurons, and sympathetic ganglion cells are examples (Mullen et al., 1992; Wolf et al., 1996). Immunohistochemically detectable NeuN protein first appears at developmental timepoints that correspond with the withdrawal of the neuron from the cell cycle and/or with the initiation of terminal differentiation of the neuron (Mullen et al., 1992). Immunoreactivity appears around E9.5 in the mouse neural tube and is extensive throughout the developing nervous system by E12.5.

Egyediség

Antibody recognizes Neuronal Nuclei.

Immunogén

Purified cell nuclei from mouse brain.

Alkalmazás

Research Category
Neuroscience
Research Sub Category
Neuronal & Glial Markers
This Milli-Mark Anti-NeuN-PE Antibody, clone A60 is validated for use in FC for the detection of NeuN.

Minőség

Evaluated by flow cytometry using U251 cells.

Fizikai forma

Protein A purified
Purified mouse monoclonal IgG1 conjugated to PE in PBS with 0.1% sodium azide and 15 mg/mL BSA

Tárolás és stabilitás

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.

Analízis megjegyzés

Control
U251 cells

Jogi információk

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Tárolási osztály kódja

10 - Combustible liquids

WGK

WGK 2

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable


Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

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Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.

Dokumentumtár megtekintése

Julio Barrera et al.
Molecular neurodegeneration, 16(1), 58-58 (2021-08-26)
In the post-GWAS era, there is an unmet need to decode the underpinning genetic etiologies of late-onset Alzheimer's disease (LOAD) and translate the associations to causation. We conducted ATAC-seq profiling using NeuN sorted-nuclei from 40 frozen brain tissues to determine
Alexey Kozlenkov et al.
Science advances, 4(9), eaau6190-eaau6190 (2018-09-29)
Brain function depends on interaction of diverse cell types whose gene expression and identity are defined, in part, by epigenetic mechanisms. Neuronal DNA contains two major epigenetic modifications, methylcytosine (mC) and hydroxymethylcytosine (hmC), yet their cell type-specific landscapes and relationship
Boxun Zhao et al.
PLoS genetics, 15(4), e1008043-e1008043 (2019-04-12)
Mounting evidence supports that LINE-1 (L1) retrotransposition can occur postzygotically in healthy and diseased human tissues, contributing to genomic mosaicism in the brain and other somatic tissues of an individual. However, the genomic distribution of somatic human-specific LINE-1 (L1Hs) insertions
Kathryn Vaillancourt et al.
iScience, 24(10), 103169-103169 (2021-10-26)
Cocaine dependence is a chronic, relapsing disorder caused by lasting changes in the brain. Animal studies have identified cocaine-related alterations in striatal DNA methylation; however, it is unclear how methylation is related to cocaine dependence in humans. We generated methylomic
Jeffrey Gu et al.
Frontiers in neuroscience, 15, 652226-652226 (2021-05-18)
Parkinson's disease (PD) and dementia with Lewy body (DLB) are the most common synucleinopathies. SNCA gene is a major genetic risk factor for these diseases group, and dysregulation of its expression has been implicated in the genetic etiologies of several

Cikkek

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