444274

MMP-2/MMP-9 Inhibitor IV

The MMP-2/MMP-9 Inhibitor IV, also referenced under CAS 292605-14-2, controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Szinonimák: MMP-2/MMP-9 Inhibitor IV, SB-3CT
• Tapasztalati képlet (Hill-képlet): C₁₅H₁₄O₃S₂
• CAS-szám: 292605-14-2
• Molekulatömeg: 306.40
• MDL-szám: MFCD09836266
• UNSPSC kód: 12352200
• NACRES: NA.77

Tulajdonságok

• Minőségi szint: 100
• Teszt: ≥95% (HPLC)
• Forma: solid
• hatékonyság: 13.9 nM K_i
• gyártó/kereskedő neve: Calbiochem^®
• tárolási körülmény: OK to freeze; protect from light
• szín: off-white
• oldhatóság: DMSO: 100 mg/mL
• kiszállítva: ambient
• tárolási hőmérséklet: −20°C
• SMILES string: [S](=O)(=O)(CC3SC3)c1ccc(cc1)Oc2ccccc2
• InChI: 1S/C15H14O3S2/c16-20(17,11-14-10-19-14)15-8-6-13(7-9-15)18-12-4-2-1-3-5-12/h1-9,14H,10-11H2
• Nemzetközi kémiai azonosító kulcs: LSONWRHLFZYHIN-UHFFFAOYSA-N

Leírás

Általános leírás

A potent, selective, slow-binding and mechanism-based inhibitor of human gelatinases, MMP-2 (K_i = 13.9 nM) and MMP-9 (K_i = 600 nM). It also exhibits a covalent mechanism based behavior in inhibition of these enzymes. This inhibitor appears to have similarity to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. Shown to directly bind to the zinc in the catalytic site of MMP-2. Does not affect the activities of MMP-1 (K_i = 206 µM) MMP-3 (K_i = 15 µM), or MMP-7 (K_i = 96 µM).

A potent, selective, slow-binding and mechanism-based inhibitor of human gelatinases, MMP-2 (K_i = 13.9 nM), and MMP-9 (K_i = 600 nM). This inhibitor appears to behave similarly to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. Also exhibits a covalent mechanism-based behavior in inhibition of these enzymes. Binds directly to the catalytic zinc ion on MMP-2.

Biokémiai/fiziológiai hatások

Cell permeable: no

Product does not compete with ATP.

Reversible: no

Kiszerelés

Packaged under inert gas

Figyelmeztetés

Toxicity: Standard Handling (A)

Egyéb megjegyzések

Krüger, A., et al. 2005. Cancer Res.65, 3523.
Kleinfeld, O., et al. 2001. J. Biol. Chem.276, 17125.
Brown, S., et al. 2000. J. Am. Chem. Soc.122, 6799.

Jogi információk

Sold under license of U.S. Patent 6,703,415.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable