164606

Aminopeptidase N/CD13 Inhibitor

The Aminopeptidase N/CD13 Inhibitor controls the biological activity of Aminopeptidase N/CD13. This small molecule/inhibitor is primarily used for Neuroscience applications.

• Szinonimák: Aminopeptidase N/CD13 Inhibitor, 4-tert-butylphenyl hydrogen 1-aminopropylphosphonate
• Tapasztalati képlet (Hill-képlet): C₁₃H₂₂NO₃P
• Molekulatömeg: 271.29
• UNSPSC kód: 12352200
• NACRES: NA.77

Tulajdonságok

• Minőségi szint: 100
• Teszt: ≥95% (HPLC)
• form: solid
• gyártó/kereskedő neve: Calbiochem^®
• tárolási körülmény: OK to freeze
• szín: white
• oldhatóság: 0.1 M NaOH: 1 mg/mL; DMSO: 1 mg/mL (Only partially soluble); water: 1 mg/mL (only partially soluble)
• kiszállítva: wet ice
• tárolási hőmérséklet: −20°C

Leírás

Általános leírás

An alpha-aminoaralkylphosphonic acid ester that acts as an aminopeptidase N/CD13 inhibitor (IC₅₀=1.1 µM). Cell growth is dose dependently inhibited by as much as ~36% and ~60% in PANC-1 and HT-1080 cells, respectively when 300 µM of compound 4d is co-treated with 30 µg/ml of TNF. When treated with compound 4d alone, cell growth is dose-dependently inhibited by as much as 26% and 36%, in the same cell lines, respectively.

An alpha-aminoaralkylphosphonic acid ester that acts as an aminopeptidase N/CD13 inhibitor (IC₅₀=1.1 µM). Cell growth is dose dependently inhibited by as much as ~36% and ~60% in PANC-1 and HT-1080 cells, respectively when 300 µM of compound 4d is co-treated with 30 µg/ml of TNF. When treated with compound 4d alone, cell growth is dose-dependently inhibited by as much as 26% and 36%, in the same cell lines, respectively.

Figyelmeztetés

Toxicity: Standard Handling (A)

Feloldás

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Egyéb megjegyzések

Grzywa, R., et al. 2010. Bioorg. Med. Chem.8, 2930.

Jogi információk

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 2
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable