14-484-M

PKCα Protein, active, 10 µg

Active, recombinant, full-length human PKCα, containing N-terminal His6 tag. For use in Kinase Assays.

• Szinonimák: PRKCA, Protein kinase C alpha type
• UNSPSC kód: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

Tulajdonságok

• biológiai forrás: human
• Minőségi szint: 100
• rekombináns: expressed in baculovirus infected Sf21 cells
• termékcsalád: Upstate^®
• specifikus aktivitás: (For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)
• eltarthatósági idő: 1 yr
• molekulatömeg: M_w 78 kDa
• tisztítva: (Ni²⁺/NTA-agarose)
• faj reaktivitás: human
• gyártó/kereskedő neve: Upstate^®
• technika/technikák: activity assay: suitable (kinase)
• elérési szám: (FUNCTION: SwissProt: P17252 # PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. ); NM_002737.2
• NCBI elérési szám: NM_002737.2
• UniProt elérési szám: P17252
• tárolási hőmérséklet: −70°C
• Géninformáció: human ... PRKCA(5578)

Leírás

Általános leírás

Research area: Apoptosis

Protein Target: PKCα

Target Sub-Family: AGC

Recombinant, full-length human PKCα, containing N-terminal His6 tag

Alkalmazás

Active, recombinant, full-length human PKCα, containing N-terminal His6 tag. For use in Kinase Assays.

Biokémiai/fiziológiai hatások

Protein kinase C-α (PKCα), an isoform of protein kinase C, exhibits an anti-apoptotic and pro-proliferative function. It is commonly upregulated in tumor cells, and its depletion has been associated with apoptosis induction. The anti-apoptotic effects of PKCα are mediated through mechanisms such as phosphorylation of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2) and activation of the pro-survival protein kinase AKT. The inhibition of PKCα leads to the activation of a PKCδ-dependent apoptotic pathway in salivary epithelial cells. PKCα regulates cell cycle progression in glioma cells by increasing the expression of p21 cyclin-dependent kinase inhibitor 1 (p21 (Waf1/Cip1)), a protein involved in cell cycle regulation.

Kiszerelés

Also available in 10 μg size and in bulk

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-484M when ordering the 250 µg size.

Minőség

routinely evaluated by phosphorylation of Histone H1.

Cél megnevezése

PKCα

Fizikai forma

Ni²⁺/NTA-agarose

Tárolás és stabilitás

1 year at -70°C

Egyéb megjegyzések

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Jogi információk

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biztonsági adatok

• Piktogramok: GHS07
• Figyelmeztetés: Warning
• Figyelmeztető mondatok: H317
• Óvintézkedésre vonatkozó mondatok: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Veszélyességi osztályok: Skin Sens. 1
• Tárolási osztály kódja: 12 - Non Combustible Liquids
• WGK: WGK 1
• Lobbanási pont (C): Not applicable