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V3388

Sigma-Aldrich

Vascular Endothelial Growth Factor (aa 207-318) human

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Szinonimák:

VEGF112, Vasculotropin

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
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About This Item

MDL-szám:
MFCD00286542
UNSPSC kód:
12352202
NACRES:
NA.32

Terméknév

Vascular Endothelial Growth Factor (aa 207-318) human, ≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

biológiai forrás

human

Minőségi szint

100

rekombináns

expressed in E. coli

Teszt

≥97% (SDS-PAGE)

Forma

lyophilized powder

hatékonyság

0.75-3.75 ng/mL ED50

molekulatömeg

predicted mol wt ~28 kDa

kiszerelés

pkg of 5 μg

tárolási körülmény

avoid repeated freeze/thaw cycles

szennyeződések

<1 EU/μg

UniProt elérési szám

P15692

tárolási hőmérséklet

−20°C

Géninformáció

human ... VEGFA(7422)

Alkalmazás

Vascular Endothelial Growth Factor (aa 207-318) human also known as VEGF 121 was used for preparing a cellular matrix hybridized with hyaluronic acid (ACM-HA) VEGF constructs which is used in measuring the VEGF-enhanced tissue-engineered bladder graft neovascularization by using dynamic contrast-enhanced MRI. The product was used for creating VEGF-impregnated tissue-engineered construct which was inserted in the critical-sized calvarial defect in the membranous parietal bone of the rabbit for examining and characterizing the angiogenesis necessary for bone formation.

Biokémiai/fiziológiai hatások

Vascular Endothelial Growth Factor (aa 207-318) human also referred to as VEGF 121 or Vasculotropin is a basic protein that induces endothelial cell growth, vasculogenesis and angiogenesis. VEGF also enhances the growth of endothelial cells isolated from cerebral cortex, fetal and adult aorta as well as human umbilical vein. Cells enhance VEGF 121 secretion from fibrin implants results in local and controlled blood vessel growth.
Potent angiogenesis inducer in vivo.

Egyéb megjegyzések

112 amino acid residue variant of human VEGF.

Fizikai forma

Lyophilized from a 0.2 μm filtered solution in 30% acetronitrile and 0.1% TFA containing 0.25 mg bovine serum albumin.

Analízis megjegyzés

The biological activity is measured by its ability to stimulate 3H-thymidine incorporation in human umbilical vein endothelial cells.

Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 3

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

Egyéni védőeszköz

Eyeshields, Gloves, type N95 (US)

Válasszon a legfrissebb verziók közül:

Analitikai tanúsítványok (COA)

Lot/Batch Number
SLBB1958V
091M1270V
071M1190V
021M1384V
031M1338V

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COA keresése

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Dokumentumtár megtekintése

Martin Ehrbar et al.
Circulation research, 94(8), 1124-1132 (2004-03-27)
Although vascular endothelial growth factor (VEGF) has been described as a potent angiogenic stimulus, its application in therapy remains difficult: blood vessels formed by exposure to VEGF tend to be malformed and leaky. In nature, the principal form of VEGF
Lisa Cartwright et al.
Journal of biomedical materials research. Part A, 77(2), 390-395 (2006-01-24)
Tissue engineered organs require an immediately perfused vascular tree. Currently, neovascularization assessment requires animal sacrifice and graft harvest. In this pilot study we assess whether neovascularization of an engineered urinary bladder construct is enhanced with vascular-derived endothelial growth factor (VEGF)
Sevan Evren et al.
Cells, tissues, organs, 192(4), 250-261 (2010-07-01)
Natural scaffolds have been shown to induce T helper 2 (TH2)-specific immune responses in host tissues; however, the precise mechanisms that underlie this immune response are unknown. Using a porcine animal model, we evaluated the role of Toll-like receptors (TLRs)
Leung, D.W., et al.
Science, 246 (1989)
Marine Beaumont et al.
NMR in biomedicine, 23(1), 48-55 (2009-08-04)
Tissue engineering is a promising technique for bone repair and can overcome the major drawbacks of conventional autogenous bone grafting. In this in vivo longitudinal study, we proposed a new tissue-engineering paradigm: inserting a biological soft-tissue construct within the bone
View All Related Papers

Cikkek

Vascular Endothelial Growth Factors (VEGF)

VEGF-A stimulates blood vessel growth via endothelial cell proliferation, migration, and survival during embryonic development.

Tudóscsoportunk valamennyi kutatási területen rendelkezik tapasztalattal, beleértve az élettudományt, az anyagtudományt, a kémiai szintézist, a kromatográfiát, az analitikát és még sok más területet.

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