13-104
MBP (myelin basic protein), bovine, purified
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
UNSPSC kód:
12352202
eCl@ss:
32160405
NACRES:
NA.41
Javasolt termékek
biológiai forrás
bovine
Minőségi szint
Forma
liquid
eltarthatósági idő
2 yr
gyártó/kereskedő neve
Upstate®
technika/technikák
activity assay: suitable
oldhatóság
water: soluble
NCBI elérési szám
UniProt elérési szám
kiszállítva
wet ice
tárolási hőmérséklet
−20°C
Géninformáció
bovine ... MBP(618684)
Általános leírás
Myelin basic protein (MBP) belongs to the intrinsically disordered protein family. It is localized in the insulating layer of nerve cells in the brain and spinal cord. It is an abundant protein found in the central nervous system (CNS).
Research area: Cell Signaling
MBP is an alkaline protein with a pI of 11.6, constituting approximately 30% of the total protein content of the myelin in the central nervous system.
MBP is an alkaline protein with a pI of 11.6, constituting approximately 30% of the total protein content of the myelin in the central nervous system.
Alkalmazás
MBP (myelin basic protein), bovine, purified has been used in western blotting and as a standard in enzyme-linked immunosorbent assay (ELISA).
Biokémiai/fiziológiai hatások
MBP can interact with various polyanionic proteins such as actin, tubulin, Ca2+-calmodulin, and clathrin, as well as negatively charged lipids. Upon binding to these proteins, MBP undergoes structural changes. It is believed to function as a membrane actin-binding protein, potentially enabling its involvement in relaying extracellular signals to the cytoskeleton in oligodendrocytes and tight junctions in myelin. External signals received by myelin or cultured oligodendrocytes lead to alterations in the phosphorylation of MBP, indicating its participation in signaling. The peptide MBP4-14 is specific for protein kinase C and is resistant to phosphatase activity. Moreover, MBP is extensively utilized in the "in gel" kinase assay, making it a vital biochemical for studying protein kinase activities.
Myelin basic protein (MBP), known as the ‘executive molecule of myelin′, helps in the formation of central nervous system (CNS) myelin. Elevated levels of MBP in the cerebrospinal fluid (CSF) are detected in acute neurological disorders like exacerbating multiple sclerosis, and traumatic brain injury. It is also observed at increased levels during chronic progressive disorders including dementia, tumor cerebri, and metabolic disorders.
Minőség
routinely evaluated by successfully phosphorylating MAP Kinase 2/Erk2, active (Catalog # 14-173)
Fizikai forma
10mM MOPS, pH 7.0, with 0.05% sodium azide
Tárolás és stabilitás
2 years at -20°C
Egyéb megjegyzések
This product is derived from bovine source. Export of this product to certain countries may be restricted. Please contact Customer Service or your local distributor to inquire about product availability and export options.
Jogi információk
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Jogi nyilatkozat
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Tárolási osztály kódja
12 - Non Combustible Liquids
WGK
nwg
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
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Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.
Az ügyfelek ezeket is megtekintették
Myelin basic protein: a multifunctional protein
Boggs JM
Cellular and Molecular Life Sciences (2006)
M Mayr et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 14(2), 261-270 (2000-02-05)
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Proceedings of the National Academy of Sciences of the United States of America, 109(8), 2860-2865 (2012-02-11)
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Purification of myelin basic protein from bovine brain
Chevalier, Dominique and Allen, Bruce G
Protein Expression and Purification, 18(2), 229-234 (2000)
A C Maroney et al.
The Journal of biological chemistry, 276(27), 25302-25308 (2001-04-28)
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