118415

ADP-HPD, Dihydrate, Ammonium Salt

≥95% (HPLC), lyophilized solid, PARG inhibitor, Calbiochem^®

• Szinonimák: ADP-HPD, Dihydrate, Ammonium Salt, Adenosine 5ʹ-diphosphate (Hydroxymethyl)pyrrolidinediol, NH₄
• Tapasztalati képlet (Hill-képlet): C₁₅H₂₃N₆O₁₂P₂ · NH₄ · 2H₂O
• Molekulatömeg: 595.39
• UNSPSC kód: 12352200
• NACRES: NA.77

Tulajdonságok

• product name: ADP-HPD, Dihydrate, Ammonium Salt, ADP-HPD, Dihydrate is an amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC₅₀ = 120 nM).
• Minőségi szint: 100
• Teszt: ≥95% (HPLC)
• form: lyophilized solid
• gyártó/kereskedő neve: Calbiochem^®
• tárolási körülmény: OK to freeze; desiccated (hygroscopic); protect from light
• szín: white
• oldhatóság: water: 5 mg/mL
• kiszállítva: ambient
• tárolási hőmérséklet: −20°C

Leírás

Általános leírás

An amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG) (IC₅₀ = 120 nM) vs. ADP-ribose (IC₅₀ = 120 mM). Also inhibits NAD glycohydrolase from Bungarus fasciatus venom at much higher concentrations (IC₅₀ = 260 µM). Does not affect the activities of either poly(ADP-ribose) polymerase (PARP) or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1 mM concentration.

An amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC₅₀ = 120 nM). Does not affect the activities of either poly(ADP-ribose) polymerase (PARP) or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1 mM concentration. Also acts as an inhibitor of NAD glycohydrolase from Bungarus fasciatus venom at much higher concentrations (IC₅₀ = 260 µM). Note: 1 set = 5 x 60 µg.

Note: 1 set = 5 x 60 µg

Biokémiai/fiziológiai hatások

Cell permeable: no

Primary Target
PARG

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 120 nM against poly(ADP-ribose) glycohydrolase (PARG)

Kiszerelés

Packaged under inert gas

Figyelmeztetés

Toxicity: Standard Handling (A)

Feloldás

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 week at -20°C.

Egyéb megjegyzések

Vispe, S., et al. 2000. Proc. Natl. Acad. Sci. USA97, 9886.
Slama, J.T., et al. 1995. J. Med. Chem.38, 389.
Slama, J.T., et al. 1995. J. Med. Chem.38, 4332.

Jogi információk

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable