P-909

Acetaminophen-D₄ solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Tapasztalati képlet (Hill-képlet): C₈D₄H₅NO₂
• CAS-szám: 64315-36-2
• Molekulatömeg: 155.19
• EC-szám: 200-659-6
• UNSPSC kód: 41116107
• NACRES: NA.24

Tulajdonságok

• grade: certified reference material
• Minőségi szint: 300
• form: liquid
• Jellemzők: Snap-N-Spike^®/Snap-N-Shoot^®
• kiszerelés: ampule of 1 mL
• gyártó/kereskedő neve: Cerilliant^®
• koncentráció: 100 μg/mL in methanol
• technika/technikák: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• alkalmazás(ok): forensics and toxicology
• format: single component solution
• tárolási hőmérséklet: −20°C
• SMILES string: [2H]c1c([2H])c(NC(C)=O)c([2H])c([2H])c1O
• InChI: 1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)/i2D,3D,4D,5D
• Nemzetközi kémiai azonosító kulcs: RZVAJINKPMORJF-QFFDRWTDSA-N

Leírás

Általános leírás

A stable-labeled internal standard suitable for quantitation of acetaminophen levels in urine, serum, or plasma by LC/MS or GC/MS for clinical toxicology, isotope dilution methods, P450 studies, and other pharmaceutical research. Acetaminophen, or Paracetamol, is a common over-the-counter COX inhibitor drug used for pain relief and fever reduction.

Alkalmazás

• Simultaneous determination of acetaminophen and oxycoDonein human plasma by LC-MS/MS and its application to a pharmacokinetic study: Highlights the application of acetaminophen-D₄ as an internal standard in pharmacokinetic studies to ensure accurate measurement of drug levels in plasma, crucial for drug development and therapeutic monitoring (Lu et al., 2018).


• Simultaneous quantification of acetaminophen and five acetaminophen metabolites in human plasma and urine by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry: Demonstrates the use of acetaminophen-D₄ in complex bioanalytical methods for studying drug metabolism and excretion in clinical pharmacology (Cook et al., 2015).


• Application of high-performance liquid chromatography/chemical reaction interface mass spectrometry for the analysis of conjugated metabolites: Discusses a method using deuterated acetaminophen (such as acetaminophen-D₄) to analyze conjugated drug metabolites, enhancing the understanding of drug metabolism pathways (Teffera and Abramson, 1994).


• Acetaminophen production in man after coadministration of acetanilid and phenacetin: A study that possibly uses deuterated compounds like acetaminophen-D₄ to trace metabolic pathways and interactions between multiple analgesics, providing insights into their pharmacokinetic behaviors (Baty and Robinson, 1977).

Jogi információk

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Piktogramok: GHS02,GHS06,GHS08
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H225,H301 + H311 + H331,H370
• Óvintézkedésre vonatkozó mondatok: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Veszélyességi osztályok: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Célzott szervek: Eyes
• Tárolási osztály kódja: 3 - Flammable liquids
• WGK: WGK 1
• Lobbanási pont (F): 49.5 °F - closed cup
• Lobbanási pont (C): 9.7 °C - closed cup