Passa al contenuto
Merck
  • Consumption of clarified grapefruit juice ameliorates high-fat diet induced insulin resistance and weight gain in mice.

Consumption of clarified grapefruit juice ameliorates high-fat diet induced insulin resistance and weight gain in mice.

PloS one (2014-10-09)
Rostislav Chudnovskiy, Airlia Thompson, Kevin Tharp, Marc Hellerstein, Joseph L Napoli, Andreas Stahl
ABSTRACT

To determine the metabolic effects of grapefruit juice consumption we established a model in which C57Bl/6 mice drank 25-50% sweetened GFJ, clarified of larger insoluble particles by centrifugation (cGFJ), ad libitum as their sole source of liquid or isocaloric and sweetened water. cGFJ and control groups consumed similar amounts of liquids and calories. Mice fed a high-fat diet and cGFJ experienced a 18.4% decrease in weight, a 13-17% decrease in fasting blood glucose, a three-fold decrease in fasting serum insulin, and a 38% decrease in liver triacylglycerol values, compared to controls. Mice fed a low-fat diet that drank cGFJ experienced a two-fold decrease in fasting insulin, but not the other outcomes observed with the high-fat diet. cGFJ consumption decreased blood glucose to a similar extent as the commonly used anti-diabetic drug metformin. Introduction of cGFJ after onset of diet-induced obesity also reduced weight and blood glucose. A bioactive compound in cGFJ, naringin, reduced blood glucose and improved insulin tolerance, but did not ameliorate weight gain. These data from a well-controlled animal study indicate that GFJ contains more than one health-promoting neutraceutical, and warrant further studies of GFJ effects in the context of obesity and/or the western diet.

MATERIALI
N° Catalogo
Marchio
Descrizione del prodotto

Sigma-Aldrich
Ossido di deuterio, 99.9 atom % D
Sigma-Aldrich
Glicerolo, ACS reagent, ≥99.5%
Sigma-Aldrich
Glicerolo, for molecular biology, ≥99.0%
Sigma-Aldrich
Glicerolo, ReagentPlus®, ≥99.0% (GC)
Sigma-Aldrich
Saccarosio, for molecular biology, ≥99.5% (GC)
Sigma-Aldrich
Saccarosio, ≥99.5% (GC)
Sigma-Aldrich
DAPI, for nucleic acid staining
Sigma-Aldrich
Saccarosio, ≥99.5% (GC), BioXtra
Sigma-Aldrich
Saccarosio, BioUltra, for molecular biology, ≥99.5% (HPLC)
Sigma-Aldrich
Ossido di deuterio, 99.9 atom % D, contains 0.05 wt. % 3-(trimethylsilyl)propionic-2,2,3,3-d4 acid, sodium salt
USP
Saccarosio, United States Pharmacopeia (USP) Reference Standard
Sigma-Aldrich
Glicerolo, 83.5-89.5% (T)
Sigma-Aldrich
Glicerolo, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for electrophoresis, ≥99% (GC)
Sigma-Aldrich
Saccarosio, ≥99.5% (GC), BioReagent, suitable for cell culture, suitable for insect cell culture
Sigma-Aldrich
Glicerolo, BioUltra, for molecular biology, anhydrous, ≥99.5% (GC)
Sigma-Aldrich
Saccarosio, ≥99.5% (GC)
Sigma-Aldrich
Glicerolo, puriss., anhydrous, 99.0-101.0% (alkalimetric)
USP
Glicerina, United States Pharmacopeia (USP) Reference Standard
Sigma-Aldrich
Saccarosio, ≥99.5% (GC), Grade II, suitable for plant cell culture
Sigma-Aldrich
Glicerolo, puriss. p.a., ACS reagent, anhydrous, dist., ≥99.5% (GC)
Sigma-Aldrich
Glicerolo, FCC, FG
Sigma-Aldrich
Ossido di deuterio, 99.9 atom % D, contains 0.75 wt. % 3-(trimethylsilyl)propionic-2,2,3,3-d4 acid, sodium salt
Sigma-Aldrich
Saccarosio, Grade I, ≥99% (GC), suitable for plant cell culture
Sigma-Aldrich
Ossido di deuterio, filtered, 99.8 atom % D
Sigma-Aldrich
Saccarosio, meets USP testing specifications
Sigma-Aldrich
Ossido di deuterio, 99.9 atom % D, contains 1 % (w/w) 3-(trimethylsilyl)-1-propanesulfonic acid, sodium salt (DSS)
Sigma-Aldrich
Glicerolo, ≥99.5%
Sigma-Aldrich
Glicerolo, BioXtra, ≥99% (GC)
Supelco
Saccarosio, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
Ossido di deuterio, 70 atom % D