SMB00287

Formycin A

from Streptomyces kaniharaensis, ≥98% (HPLC)

• Synonym(e): 7-Amino-3-(β-D-ribofuranosyl)-1H-pyrazolo[4,3-d]pyrimidin
• Empirische Formel (Hill-System): C₁₀H₁₃N₅O₄
• CAS-Nummer: 6742-12-7
• Molekulargewicht: 267.24
• Beilstein: 624229
• MDL-Nummer: MFCD00036807
• UNSPSC-Code: 51102829
• PubChem Substanz-ID: 329824924
• NACRES: NA.85

Eigenschaften

• Biologische Quelle: Streptomyces kaniharaensis
• Qualitätsniveau: 200
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: (Keep container tightly closed in a dry and well-ventilated place.)
• Farbe: white to off-white
• Löslichkeit: DMSO: soluble 1 mg/mL; H₂O: soluble 3 mg/mL
• Wirkungsspektrum von Antibiotika: viruses (Antiretroviral)
• Wirkungsweise: enzyme | inhibits
• Lagertemp.: −20°C
• SMILES String: Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
• InChI: 1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
• InChIKey: OIRDTQYFTABQOQ-KQYNXXCUSA-N
• Angaben zum Gen: human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140)

Beschreibung

Allgemeine Beschreibung

Chemical structure: nucleoside

Formycin A is an adenosine analog, and is cytotoxic in nature. It acts as a substrate for the human enzymes human erythrocytic adenosine deaminase and adenosine kinase.

Biochem./physiol. Wirkung

Formycin A (FA) is a C-nucleoside that inhibits the E.coli enzyme purine nucleoside phosphorylase (PNP). FA was found to upsurge insulin release elevated by glucose, and was also shown to inhibit 5′-Methylthioadenosine/S-adenosylhomocysteine (MTA/AdoHcy) nucleosidase, an enzyme important in the recycling of methionine. Research has shown FA is an antiretroviral agent against HIV-1, targeting reverse transcription.

Formycin A possess antitumor function, along with its antibacterial and antiviral activity.

Verpackung

10MG

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place.

Store the product sealed at –20 °C. Under these conditions the product is stable for at least 4 years.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable