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M2525

Sigma-Aldrich

Mianserin -hydrochlorid

Synonym(e):

1,2,3,4,10,14b-Hexahydro-2-methyl-dibenzo[c,f]pyrazino[1,2-a]azepin -hydrochlorid

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About This Item

Empirische Formel (Hill-System):
C18H20N2 · HCl
CAS-Nummer:
21535-47-7
Molekulargewicht:
300.83
EG-Nummer:
244-426-7
MDL-Nummer:
MFCD00055072
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278125
NACRES:
NA.77

Löslichkeit

H2O: 3.4 mg/mL
ethanol: 5.6 mg/mL

Ersteller

Organon

Lagertemp.

2-8°C

SMILES String

Cl.CN1CCN2C(C1)c3ccccc3Cc4ccccc24

InChI

1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H

InChIKey

YNPFMWCWRVTGKJ-UHFFFAOYSA-N

Angaben zum Gen

human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , HRH1(3269) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358)

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Anwendung

Mianserin hydrochloride has been used:
  • as a reversible antagonist for serotonergic -protein coupled receptor (GPCR) - G-protein protein-coupled receptor (S7.1R)
  • as an antidepressant in hippocampal astrocytes to test its effect on brain-derived neurotrophic factor (BDNF) mRNA expression
  • as a 5-hydroxytryptamine (5-HT) receptor antagonist to study its effect on serotonin modulation

Biochem./physiol. Wirkung

Mianserin is a tetracyclic compound with sedative property. It lacks anticholinergic activity and is not effective on serotoninergic mechanisms. Mianserin is eliminated post biotransformation as hydroxylation, N-oxidation and N-demethylation products.
Antidepressivum; Antagonist/inverser Agonist an 5-HT2-Serotonin-Rezeptoren, blockiert auch den H1-Histamin-Rezeptor und den α2 Adrenozeptor.

Leistungsmerkmale und Vorteile

This compound was developed by Organon. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Angaben zur Herstellung

Solutions may be stored for several days at 4°C.

Anwendung

Produkt-Nr.
Beschreibung
Preisangaben

G004469

HPLC Analysis of Mianserin Enantiomers on Astec® CHIROBIOTIC® V2, application for HPLC

G004633

HPLC Analysis of Mianserin Enantiomers on Astec® CHIROBIOTIC® V, application for HPLC

G004992

HPLC Analysis of Mianserin Enantiomers on Astec® Cellulose DMP, POM Conditions, application for HPLC

G004993

HPLC Analysis of Mianserin Enantiomers on Astec® Cellulose DMP, application for HPLC

G005003

HPLC Analysis of Mianserin Enantiomers on Astec® Cellulose DMP, LC/MS Conditions, application for HPLC

G005006

HPLC Analysis of Mianserin Enantiomers on Astec® Cellulose DMP (No Additives), application for HPLC

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

I M Leitch et al.
The Journal of pharmacy and pharmacology, 44(4), 315-320 (1992-04-01)
Some in-vitro pharmacological effects of a novel analogue of mianserin, 2-carboxamidino-1,2,3,4,10,14b-hexahydrodibenzo (c,f) pyrazino (1,2-alpha) azepine hydrochloride (FCC5) have been studied. FCC5 was a non-competitive antagonist of both histamine-induced contractions of the guinea-pig ileum and 5-HT-induced contractions of rat fundal strips
Modulatory effects of the serotonergic and histaminergic systems on reaction to light in the crustacean Gammarus pulex
Perrot-Minnot MJ, et al.
Neuropharmacology, 75, 31-37 (2013)
T de Boer
International clinical psychopharmacology, 10 Suppl 4, 19-23 (1995-12-01)
Mirtazapine is a new antidepressant with a unique mode of action: it preferentially blocks the noradrenergic alpha2-auto- and heteroreceptors held responsible for controlling noradrenaline and serotonin release. In addition, mirtazapine has a low affinity for serotonin (5-HT)1A receptors but potently
Anti-depressant fluoxetine reveals its therapeutic effect via astrocytes
Kinoshita M, et al.
EBioMedicine, 32(3), 72-83 (2018)
P A Lavoie et al.
European journal of pharmacology, 369(3), 387-390 (1999-05-04)
In order to test potential links with other stereospecific neurobiological effects of mianserin, the present study explored the stereospecificity for inhibition of depolarization-induced Ca2+ uptake by mianserin. Synaptosomes from rat hippocampus were incubated with 45Ca2+ in either resting or depolarizing
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