I6125
Jodacetamid
≥99% (NMR), crystalline
Synonym(e):
α-Iodoacetamide, 2-Iodoacetamide
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Alle Fotos(5)
About This Item
Lineare Formel:
ICH2CONH2
CAS-Nummer:
Molekulargewicht:
184.96
Beilstein:
1739080
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352202
PubChem Substanz-ID:
NACRES:
NA.77
Empfohlene Produkte
Biologische Quelle
synthetic (organic)
Assay
≥99% (NMR)
Form
crystalline
mp (Schmelzpunkt)
92-95 °C (lit.)
Löslichkeit
H2O: soluble 0.5 M, clear, colorless
Lagertemp.
2-8°C
SMILES String
NC(=O)CI
InChI
1S/C2H4INO/c3-1-2(4)5/h1H2,(H2,4,5)
InChIKey
PGLTVOMIXTUURA-UHFFFAOYSA-N
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Anwendung
- A Mass Spectrometry Strategy for Protein Quantification Based on the Differential Alkylation of Cysteines Using Iodoacetamide and Acrylamide.: This study presents a novel mass spectrometry method for quantifying proteins by differentially alkylating cysteines with iodoacetamide and acrylamide, enhancing the accuracy of protein quantification in complex samples. (Virág et al., 2024).
- Laminarin ameliorates iodoacetamide-induced functional dyspepsia via modulation of 5-HT(3) receptors and the gut microbiota.: Research demonstrates that laminarin can mitigate functional dyspepsia induced by iodoacetamide through modulating 5-HT(3) receptors and altering gut microbiota composition, offering potential therapeutic benefits. (Liu et al., 2024).
- Redox proteomics in melanoma cells: An optimized protocol.: This paper describes an optimized redox proteomics protocol using iodoacetamide, which facilitates the identification of redox-sensitive proteins in melanoma cells, aiding in the understanding of redox regulation in cancer. (Cunha et al., 2024).
- Molecular targets of cisplatin in HeLa cells explored through competitive activity-based protein profiling strategy.: Utilizing iodoacetamide in competitive activity-based protein profiling, this study identifies molecular targets of cisplatin in HeLa cells, providing insights into the drug′s mechanisms. (Chen et al., 2024).
- Development and Comparison of 4-Thiouridine to Cytidine Base Conversion Reaction.: This research compares base conversion reactions involving 4-thiouridine and cytidine, with iodoacetamide playing a crucial role in the reaction mechanism, contributing to advancements in nucleotide chemistry. (Ohashi et al., 2024).
Biochem./physiol. Wirkung
Iodacetamid dient als Alkylierungsreagens für Cysteinreste bei der Peptidsequenzierung. Es ist ein irreversibler Inhibitor von Enzymen mit Cystein im aktiven Zentrum. Mit Histidinresten reagiert es sehr viel langsamer, aber diese Aktivität ist für die Hemmung der Ribonuklease verantwortlich.
Signalwort
Danger
H-Sätze
Gefahreneinstufungen
Acute Tox. 3 Oral - Aquatic Chronic 4 - Resp. Sens. 1 - Skin Sens. 1
Lagerklassenschlüssel
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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