900831

3-(3-(But-3-yn-1-yl)-3H-diazirin-3-yl)propanoic acid

• Synonym(e): Carboxyl diazirine alkyne, Probe building block
• Empirische Formel (Hill-System): C₈H₁₀N₂O₂
• CAS-Nummer: 1450754-37-6
• Molekulargewicht: 166.18
• MDL-Nummer: MFCD31433997
• UNSPSC-Code: 12352106

Eigenschaften

• Form: liquid
• Qualitätsniveau: 100
• Eignung der Reaktion: reaction type: click chemistry
• Verfügbarkeit: available only in USA
• Lagertemp.: −20°C
• SMILES String: C#CCCC1(N=N1)CCC(O)=O

Beschreibung

Anwendung

Used for chemical probe synthesis, this trifunctional building block contains a light-activated diazirine, alkyne tag, and carboxylic acid synthetic handle. When appended to a ligand or pharmacophore through its acid linker, this building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Sonstige Hinweise

Design and Synthesis of Minimalist Terminal Alkyne-Containing Diazirine Photo-Crosslinkers and Their Incorporation into Kinase Inhibitors for Cell- and Tissue-Based Proteome Profiling

Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein

Technology Spotlight: Trifuctional Probe Building Blocks

Sicherheitshinweise

• Piktogramme: GHS02
• Signalwort: Danger
• H-Sätze: H242
• P-Sätze: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Gefahreneinstufungen: Self-react. C
• Lagerklassenschlüssel: 5.2 - Organic peroxides and self-reacting hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable