X4875
Xanthine Oxidase from bovine milk
Grade IV, ammonium sulfate suspension, ≥0.1 units/mg protein
Sinônimo(s):
XOD, Xanthine:oxygen oxidoreductase
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About This Item
Número CAS:
Número da licença da enzima:
1.17.3.2.
Número CE:
Número MDL:
Código UNSPSC:
12352204
NACRES:
NA.54
Produtos recomendados
fonte biológica
bovine milk
tipo
Grade IV
forma
ammonium sulfate suspension
atividade específica
≥0.1 units/mg protein
temperatura de armazenamento
2-8°C
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Descrição geral
Research area: Cell CycleXanthineoxidase (XO) is a homodimer. It is made up of two sub-units each made up of onemolybdenum and two iron-sulphur (2Fe-2S) centers.
Formerly E.C. 1.1.3.22
Aplicação
Xanthine Oxidase from bovine milk has been used in superoxide dismutaseactivity assay.Xanthine oxidase may be suitable for producing amperometric biosensors and designing-flavonoid-type inhibitors against XO for treating inflammatory diseases, gout, and hyperuricemia. It may also be used in the synthesis of superoxide because of aldehyde oxidation.
Ações bioquímicas/fisiológicas
Although xanthine oxidase is found widely distributed in multiple tissues, it is highly expressed in endothelial and epithelial cells. Its expression was also increased in infected tissues where it was shown to have an anti-microbial effect due to its ability to generate reactive oxygen species. Xanthineoxidase plays an important role in catalyzing the hydroxylation ofhypoxanthine to Xanthine. Later, xanthine is converted to uric acid isexcreted by the kidneys.
Xanthine oxidase is a molybdenum-containing enzyme that is found in the cytosol, and may be strongly inhibited by flavonoids. It plays a vital role in the metabolism of some drugs, as well as purines and pyrimidines. It is also known to be a biological source of reactive oxygen species.
Definição da unidade
One unit will convert 1.0 μmole of xanthine to uric acid per min at pH 7.5 at 25 °C. Approx. 50% of the activity is obtained with hypoxanthine as substrate.
forma física
Suspension in 2.3 M (NH4)2SO4 containing 1 mM sodium salicylate
Nota de análise
Protein determined by biuret
Palavra indicadora
Danger
Frases de perigo
Declarações de precaução
Classificações de perigo
Resp. Sens. 1
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
Certificados de análise (COA)
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Artigos
Instructions for working with enzymes supplied as ammonium sulfate suspensions
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