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T5651

Sigma-Aldrich

Tetrodotoxin with Citrate Buffer

pH 4.8, powder

Sinônimo(s):

Fugu poison, Maculotoxin, TTX, Tarichatoxin

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About This Item

Fórmula empírica (Notação de Hill):
C11H17N3O8
Número CAS:
4368-28-9
Peso molecular:
319.27
Beilstein:
49176
Número MDL:
MFCD00213719
Código UNSPSC:
12352200
ID de substância PubChem:
24900308

forma

powder

disponibilidade

not available in USA

pH

4.8

solubilidade

H2O: soluble (stable at pH 4-5 if stored frozen)
strong acid or alkaline solutions: unstable (destroyed by boiling at pH 2.)

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

OC[C@@]1(O)[C@H]2OC3(O)OC1C4[C@@H](O)NC(=N)NC4([C@@H]2O)[C@@H]3O

InChI

1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2?,3-,4?,5+,6-,7+,9+,10?,11?/m1/s1

chave InChI

CFMYXEVWODSLAX-IXUBDLNJSA-N

Informações sobre genes

rat ... Scnn1g(24768)

Aplicação

Tetrodotoxin has been used to study its effects on microglial functions in rats2. This toxin has also been used to inactivate lateral magnocellular nucleus of the nidopallium (LMAN) in juvenile zebra finch. This study reported that the toxin causes a decrease in sequence and acoustic variability which result in the production of a stereotyped song by the motor pathway3.

Ações bioquímicas/fisiológicas

Reversible, selective blocker of Na+ channels; blocks propagation of impulses in excitable membranes. Used to characterize sodium channels in excitable membranes and to study the role of sodium channels in normal physiology and disease.

Embalagem

Vial contains 1 mg of tetrodotoxin and approx. 5 mg citrate buffer, pH 4.8.

Nota de preparo

The product is water soluble and stable at pH 4-5 if it is stored frozen. It is unstable in strong acid and alkaline solutions and is rapidly destroyed by boiling at pH 2 and below.

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H300

Declarações de precaução

P301 + P330 + P331 + P310

Classificações de perigo

Acute Tox. 1 Oral

Código de classe de armazenamento

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Pulsed focused ultrasound (pFUS) technology is being developed for clinical neuro/immune modulation and regenerative medicine. Biological signal transduction of pFUS forces can require mechanosensitive or voltage-gated plasma membrane ion channels. Previous studies suggested pFUS is capable of activating either channel
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