The recommended storage temperature for this material is ambient or room temperature. Studies have not been conducted to evaluate the stability or shelf life impact of the product when stored at other temperatures. In the original sealed container, the compound is quite stable at room temperature. Please see the link below to review additional information available in the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/366/380/r8875pis.pdf
R8875
Rotenone
≥95% (HPLC), powder, NADH-CoQ reductase inhibitor
Faça loginpara ver os preços organizacionais e de contrato
Selecione um tamanho
1 G
R$ 767,00
5 G
R$ 2.314,00
10 G
R$ 3.569,00
25 G
R$ 5.990,00
Selecione um tamanho
Alterar visualização
1 G
R$ 767,00
5 G
R$ 2.314,00
10 G
R$ 3.569,00
25 G
R$ 5.990,00
About This Item
Fórmula empírica (Notação de Hill):
C23H22O6
Número CAS:
Peso molecular:
394.42
Beilstein:
6773081
Número CE:
Número MDL:
Código UNSPSC:
12352202
ID de substância PubChem:
NACRES:
NA.77
Produtos recomendados
Nome do produto
Rotenone, ≥95%
Nível de qualidade
Ensaio
≥95%
p.e.
210-220 °C/0.5 mmHg (lit.)
pf
159-164 °C (lit.)
cadeia de caracteres SMILES
COc1cc2OCC3Oc4c5C[C@@H](Oc5ccc4C(=O)C3c2cc1OC)C(C)=C
InChI
1S/C23H22O6/c1-11(2)16-8-14-15(28-16)6-5-12-22(24)21-13-7-18(25-3)19(26-4)9-17(13)27-10-20(21)29-23(12)14/h5-7,9,16,20-21H,1,8,10H2,2-4H3/t16-,20-,21+/m1/s1
chave InChI
JUVIOZPCNVVQFO-HBGVWJBISA-N
Procurando produtos similares? Visita Guia de comparação de produtos
Descrição geral
Rotenone belongs to the retinoid family. It is naturally present in Leguminosa plants and is considered to be cytotoxic. It is commonly used as an insecticide and a pesticide.[1]
Aplicação
Ações bioquímicas/fisiológicas
Inhibitor of mitochondrial electron transport.
Rotenone is an inhibitor of mitochondrial electron transport at nicotinamide adenine dinucleotide (NADH):ubiquinone oxidoreductase. It is readily absorbed through the exoskeletons of arthropods, but poorly absorbed cutaneously or from the gastrointestinal tract of mammals. Rotenone acts as a neurotoxic agent which can produce Parkinson-like condition to serve as an animal model for the study of etiology and interventions. The primary mechanism of action of rotenone is complex I inhibition, followed by the generation of oxidative stress and oxidative damage. Because rotenone is lipophilic, it readily penetrates the brain, where it attaches to and inhibits mitochondrial complex I of electron chain transport (ETC).
Nota de preparo
This product is soluble in DMSO at 0.5 mg/ml. Other sources suggest it can be dissolved in DMSO up to 100 mM, however this has not been verified.
Palavra indicadora
Danger
Frases de perigo
Declarações de precaução
Classificações de perigo
Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Órgãos-alvo
Respiratory system
Código de classe de armazenamento
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Classe de risco de água (WGK)
WGK 3
Escolha uma das versões mais recentes:
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Os clientes também visualizaram
Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism
Fendt SM, et al.
Cancer Research (2013)
Parkinson's Disease and Movement Disorders, 81-81 (2007)
Loss of Sirt1 promotes prostatic intraepithelial neoplasia, reduces mitophagy, and delays PARK2 translocation to mitochondria
Di SG, et al.
The American Journal of Pathology, 185(1), 266-279 (2015)
Jin Bu et al.
Life sciences, 231, 116581-116581 (2019-06-21)
The aims of this study were to investigate the effect of colonic electrical stimulation (CES) on delayed colonic transit in Parkinson's disease (PD) model induced by rotenone and its possible mechanisms. Sprague-Dawley male rats were implanted with a pair of
Overexpression of TFAM or twinkle increases mtDNA copy number and facilitates cardioprotection associated with limited mitochondrial oxidative stress
Ikeda M, et al.
PLoS ONE, 10(3), e0119687-e0119687 (2015)
-
For how long can the product maintain stability in powder form at 4 °C or -80 °C?
1 answer-
Helpful?
-
-
Can aliquots of rotenone resuspended in DMSO be stored at -20C?
1 answer-
The solution stability has not been determined. However, a similar product, 557368, notes that "following reconstitution, aliquot, flush with nitrogen, and store at -70°C. Stock solutions are stable for up to 1 month at -70°C".
Helpful?
-
-
What is the solubility in other compounds ?
1 answer-
This product is tested for solubility at 50 mg/mL in chloroform. Rotenone is poorly soluble in water at approximately 0.25-0.50 uM. Other options include Ethanol and DMSO.
Ethanol: 5 mg/mL (higher concentrations may be achieved with heat and sonication)
DMSO: 50 mg/mLHelpful?
-
-
What's the solubility in DMSO
1 answer-
This product is soluble in DMSO at 0.5 mg/ml. Other sources suggest it can be dissolved in DMSO up to 100 mM, however this has not been verified.
Helpful?
-
Active Filters
Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.
Entre em contato com a assistência técnica
