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75351

Sigma-Aldrich

Oligomycin A

Oligomycin A

≥99% (HPLC)

Sinônimo(s):

MCH 32

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5 MG
R$ 2.154,00

R$ 2.154,00

Disponível para enviar em10 de abril de 2025Detalhes

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5 MG
R$ 2.154,00

About This Item

Fórmula empírica (Notação de Hill):
C45H74O11
Número CAS:
579-13-5
Peso molecular:
791.06
Beilstein:
5702132
Número CE:
209-437-3
Número MDL:
MFCD00065705
Código UNSPSC:
51102829
ID de substância PubChem:
57652563
NACRES:
NA.76

R$ 2.154,00

Disponível para enviar em10 de abril de 2025Detalhes

Solicite uma grande encomenda

Ensaio

≥99% (HPLC)

Formulário

powder

cor

white to off-white

solubilidade

DMSO: soluble

espectro de atividade do antibiótico

fungi

Modo de ação

enzyme | inhibits

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

CCC1CCC2OC3(CC[C@@H](C)C(C[C@H](C)O)O3)[C@H](C)C(OC(=O)\C=C\[C@@H](C)[C@H](O)[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@H](C)C(=O)[C@@](C)(O)[C@H](O)[C@@H](C)C\C=C\C=C\1)[C@H]2C

InChI

1S/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13+,17-15+,21-18+/t25-,26-,27+,28+,29+,30-,31+,32+,33-,34?,35?,36?,38+,40-,41?,42-,44+,45?/m1/s1

chave InChI

MNULEGDCPYONBU-VVXVDZGXSA-N

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Categorias relacionadas

Descrição geral

Chemical structure: macrolide

Aplicação

Oligomycin was used to inhibit sucrose synthesis and 14C translocation in sunflower leaves, to study antibiotic resistance, and to study carotid chemoreceptor responses to O2 and CO2 in the cat.[1][2] Inhibits the growth of Rhodotorula glutinis, Aspergillus niger and other molds.[3]

Ações bioquímicas/fisiológicas

Oligomycin blocks oxidative phosphorylation and the electron transport chain by inhibiting membrane bound mitochondrial ATP synthase (ATPase) and proton channel (pump, FO subunit) blocker.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Outras notas

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. Keep in a dry place.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
0000411118
0000411118
0000420085
0000420085
0000299581

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Hidetaka Kioka et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(1), 273-278 (2013-12-18)
The oxidative phosphorylation (OXPHOS) system generates most of the ATP in respiring cells. ATP-depleting conditions, such as hypoxia, trigger responses that promote ATP production. However, how OXPHOS is regulated during hypoxia has yet to be elucidated. In this study, selective
Isolation of oligomycin A as a result of screening for antagonists of lipids.
Y Nakakita et al.
The Journal of antibiotics, 33(5), 514-516 (1980-05-01)
Translocation of organic compounds in sunflower III. Effect of oligomycin, ouabain and phlorizin on translocation of sugars.
Michi Shiroya and Mariko Kura
Plant & Cell Physiology, 20, 369-374 (1979)
Differential effects of oligomycin on carotid chemoreceptor responses to O2 and CO2 in the cat.
M. Shirahata, S. Andronikou, et. Al
Journal of Applied Physics, 63, 2084-2092 (1987)
Catherine G Burke et al.
Scientific reports, 9(1), 11489-11489 (2019-08-09)
Early life environmental exposures drive lasting changes to the function of the immune system and can contribute to disease later in life. One of the ways environmental factors act is through cellular receptors. The aryl hydrocarbon receptor (AHR) is expressed
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Questions

1–5 of 5 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. For how long does the product remain stable once dissolved, aliquoted and stored at -20°C?

    1 answer

    1. Storage of stock solutions at -20°C is stable for 1 month.

      Helpful?

  4. Does this product contain thimerosal or any mercury-containing preservatives?

    1 answer

    1. This is a pure product, not containing any preservative or thimerosal.

      Helpful?

  5. What's it's solubility in dmso

    1 answer

    1. This product is not tested for solubility in DMSO, however other Oligomycin products have been found to be soluble at in DMSO at 50 mg/ml.

      Helpful?

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