Q1125

Quinine hydrochloride dihydrate

99-101% (titration), potassium channel blocker

• Fórmula empírica (Notação de Hill): C₂₀H₂₄N₂O₂ · HCl · 2H₂O
• Número CAS: 6119-47-7
• Peso molecular: 396.91
• Número CE: 205-001-1
• Número MDL: MFCD00078498
• Código UNSPSC: 12352210
• ID de substância PubChem: 57654577
• NACRES: NA.77

Propriedades

• Nome do produto: Quinine hydrochloride dihydrate,
• solubilidade: H₂O: 0.25/5 g/mL, clear, colorless
• espectro de atividade do antibiótico: parasites
• Modo de ação: enzyme | inhibits
• cadeia de caracteres SMILES: O.Cl.[H][C@]1(C[C@@H]2CC[N@H]1C[C@@H]2C=C)[C@H](O)c3ccnc4ccc(OC)cc34
• InChI: 1S/C20H24N2O2.ClH.H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H;1H2/t13-,14-,19-,20+;;/m0../s1
• chave InChI: SGVZDMWHXVXUBY-HZQSTTLBSA-N

Descrição

Descrição geral

Quinine is derived from the stem of cinchona (quina-quina) tree.[1] It is an alkaloid having various applications in the field of medicine.[2] Quinine is a basic compound with aryl amino alcohol group.[1]

Aplicação

Quinine hydrochloride dihydrate has been used in Drosophila larval behavioral assay.[3] It has also been used in taste preference analysis among rats.[4]

Ações bioquímicas/fisiológicas

Potassium channel blocker

Quinine is widely used in the treatment of malaria. It possesses erythrocytic and gametocytocidal action against Plasmodium sp. It also serves as an analgesic drug. Upon administration, quinine is present mostly bound to α-1 acid glycoprotein in the body fluids. Quinine has the ability to cross the placenta and the blood brain barrier. It has a half-life of 11-18 hours. Tinnitus, hearing defects, nausea and headache are some of its side effects.[1]

Informações de segurança

• Pictogramas: GHS08,GHS07
• Palavra indicadora: Danger
• Frases de perigo: H302,H317,H334
• Declarações de precaução: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Classificações de perigo: Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Faceshields, Gloves