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Q1250

Sigma-Aldrich

Quinine hemisulfate salt monohydrate

synthetic, ≥90% (HPLC)

Sinônimo(s):

Quinine sulfate (2:1) (salt) dihydrate

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About This Item

Fórmula empírica (Notação de Hill):
C20H24N2O2 · 0.5H2O4S · H2O
Número CAS:
207671-44-1
Peso molecular:
391.47
Beilstein:
6113937
Número MDL:
MFCD00150790
Código UNSPSC:
12352210
ID de substância PubChem:
57654578
NACRES:
NA.77

fonte biológica

synthetic

Ensaio

≥90% (HPLC)

pf

~225 °C (dec.) (lit.)

solubilidade

H2O: slightly soluble 1.2 mg/mL
ethanol: 8 mg/mL

espectro de atividade do antibiótico

parasites

Modo de ação

enzyme | inhibits

originador

Bayer

cadeia de caracteres SMILES

O.O.OS(O)(=O)=O.COc1ccc2nccc([C@@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1.COc5ccc6nccc([C@@H](O)C7CC8CCN7C[C@@H]8C=C)c6c5

InChI

1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14-,19-,20+;;;/m00.../s1

chave InChI

ZHNFLHYOFXQIOW-LPYZJUEESA-N

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Aplicação

Quinine hemisulfate salt monohydrate has been used as a stimuli to evaluate its influence on sensory and cognitive factors.

Ações bioquímicas/fisiológicas

Potassium channel blocker. Antimalarial, anticholinergic, antihypertensive, and hypoglycemic agent; alkaloid originally isolated from the Cinchona family of South American trees. Inhibits mitochondrial ATP-regulated potassium channel. Used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.
Quinine has analgesic property.

Características e benefícios

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319,H335

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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E M Clement et al.
Neuropharmacology, 37(7), 945-951 (1998-10-17)
Quinine and quinidine are reported to potentiate the behavioural effects of serotonergic agents and monoamine uptake inhibitors. We have therefore investigated the presynaptic actions of quinine and quinidine on monoamine uptake and release in rat brain tissue in vitro. Quinidine
A Hedman et al.
Journal of pharmaceutical sciences, 87(4), 457-461 (1998-04-21)
The pharmacokinetic interaction between quinidine and digoxin in patients is well-known, in general requiring a dose reduction of digoxin in patients concomitantly treated with quinidine. Quinine, the diastereomer of quinidine, has not been as extensively studied in this respect. In
Elizabeth A Sneddon et al.
Alcoholism, clinical and experimental research, 44(7), 1400-1409 (2020-05-31)
More women are being diagnosed with alcohol use disorder (AUD), are increasing the amount of alcohol they are drinking, and are partaking in risky drinking behaviors. Compulsive drinking which persists despite negative consequences is a hallmark of AUD. Preclinical aversion-resistant
Elizabeth A Sneddon et al.
Alcoholism, clinical and experimental research, 43(2), 243-249 (2018-11-16)
Alcohol use disorder is characterized by compulsive alcohol intake, or drinking despite negative consequences. Previous studies have shown that female rodents have a heightened vulnerability to drug use across different stages of the addictive cycle, but no previous studies have
Both perceptual and conceptual factors influence taste-odor and taste-taste interactions
Frank RA, et al.
Perception & Psychophysics, 54(3), 343-354 (1993)
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