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Q0132

Quinine sulfate

meets USP testing specifications, monograph mol wt. 782.94 ((C20H24N2O2)2 . H2SO4 . 2H2O)

Sinônimo(s):

Quinine hemisulfate salt monohydrate, Quinine sulfate (2:1) (salt) dihydrate

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About This Item

Fórmula empírica (Notação de Hill):
C20H24N2O2 · 0.5H2O4S · H2O
Número CAS:
207671-44-1
Peso molecular:
391.47
Beilstein:
6113937
Número MDL:
MFCD00150790
Código UNSPSC:
12352210
ID de substância PubChem:
24899321
NACRES:
NA.21

Agency

USP/NF
meets USP testing specifications

peso molecular

monograph mol wt. 782.94

pf

~225 °C (dec.) (lit.)

espectro de atividade do antibiótico

parasites

Modo de ação

enzyme | inhibits

cadeia de caracteres SMILES

O.O.OS(O)(=O)=O.COc1ccc2nccc([C@@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1.COc5ccc6nccc([C@@H](O)C7CC8CCN7C[C@@H]8C=C)c6c5

InChI

1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14-,19-,20+;;;/m00.../s1

chave InChI

ZHNFLHYOFXQIOW-LPYZJUEESA-N

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Aplicação

Use to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites, the toxicity of heme (FP)-complexes and to inhibit mitochondrial ATP-regulated potassium channel.

Ações bioquímicas/fisiológicas

Potassium channel blocker. Antimalarial, anticholinergic, antihypertensive, and hypoglycemic agent; alkaloid originally isolated from the Cinchona family of South American trees. Inhibits mitochondrial ATP-regulated potassium channel. Used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319,H335

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
SLCF3150
SLCD5540
SLBX2275
SLBW2571
SLBV1377

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(-)-Quinine phyproof® Reference Substance

PHL80962

(-)-Quinine

Quinine certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Supelco

69311

Quinine

Quinine hydrochloride dihydrate

Sigma-Aldrich

Q1125

Quinine hydrochloride dihydrate

(-)-Quinine for resolution of racemates for synthesis

Sigma-Aldrich

8.02304

(-)-Quinine

Quinine hydrochloride dihydrate suitable for fluorescence, BioReagent, ≥98.0% (NT)

Sigma-Aldrich

22630

Quinine hydrochloride dihydrate

Quinina ≥95%, FG

Sigma-Aldrich

W297607

Quinina

Quinine hydrochloride dihydrate tested according to Ph. Eur.

Sigma-Aldrich

22632

Quinine hydrochloride dihydrate

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