L2023

Leupeptin trifluoroacetate salt

powder, ≥90% (HPLC)

• Sinônimo(s): Acetyl-Leu-Leu-Arg-al trifluoroacetate salt
• Fórmula empírica (Notação de Hill): C₂₀H₃₈N₆O₄ · xC₂HF₃O₂
• Número CAS: 147385-61-3
• Peso molecular: 426.55 (free base basis)
• Número MDL: MFCD00133458
• Código UNSPSC: 12352202
• ID de substância PubChem: 329817397
• NACRES: NA.77

Propriedades

• product name: Leupeptin trifluoroacetate salt, ≥90% (HPLC), microbial
• fonte biológica: microbial
• Nível de qualidade: 200
• Ensaio: ≥90% (HPLC)
• forma: powder
• solubilidade: H₂O: 10 mM (Solutions are stable only a few hours. Stock solutions are stable up to 6 months at −20 °C.)
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: OC(=O)C(F)(F)F.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O
• InChI: 1S/C20H38N6O4.C2HF3O2/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;3-2(4,5)1(6)7/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);(H,6,7)/t15-,16-,17-;/m0./s1
• chave InChI: WUHGBZVQELGOMH-FRKSIBALSA-N

Descrição

Ações bioquímicas/fisiológicas

Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)

Nota de análise

Leupeptin gives multiple peaks on HPLC because of the formation of tautomeric isomers in solution. Majority of contaminating peptide is racemized leupeptin.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)