Pular para o conteúdo
Merck
Todas as fotos(1)

Documentos Principais

I3657

Sigma-Aldrich

Insulin-Like Growth Factor Binding Protein-2 from mouse

≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

Sinônimo(s):

IGFBP-2

Faça loginpara ver os preços organizacionais e de contrato

Selecione um tamanho

25 μG
R$ 5.994,00

R$ 5.994,00

Previsão de entrega em23 de maio de 2025

Todas as fotos(1)

Selecione um tamanho

Alterar visualização
25 μG
R$ 5.994,00

About This Item

Número MDL:
MFCD02099094
Código UNSPSC:
51111800
NACRES:
NA.32

R$ 5.994,00

Previsão de entrega em23 de maio de 2025

fonte biológica

mouse

Nível de qualidade

200

recombinante

expressed in NSO cells

Ensaio

≥95% (SDS-PAGE)

Formulário

lyophilized powder

potência

0.125-0.5 mg per mL ED50

peso molecular

~35 kDa by SDS-PAGE (reducing)
calculated mol wt 29.4 kDa

embalagem

pkg of 25 μg

técnica(s)

cell culture | mammalian: suitable

Impurezas

endotoxin, tested

nº de adesão UniProt

D3YU40

temperatura de armazenamento

−20°C

Informações sobre genes

mouse ... Igfbp2(16008)

Descrição geral

IGFBP2 (insulin-like growth factor binding protein 2) belongs to the IGFBP family of proteins. The protein has two HBD (heparin-binding domain-1) domains.[1][2] It is a secreted protein.[3]

Ações bioquímicas/fisiológicas

During development, insulin-like growth factor binding protein-2 is expressed in a number of tissues with the highest expression level found in the central nervous system. IGFBP-2 exhibits a 2-10 fold higher affinity for IGF II than for IGF I. Mouse and human IGFBP-2 share approximately 82% homology.
Exhibits a 2-10 fold higher affinity for IGF II than for IGF I.
IGFBP2 (insulin-like growth factor binding protein 2) works along with IGF-I (insulin like growth factor I) and regulates cellular proliferation and differentiation.[4] It mainly binds to IGFs and restricts their association to other receptors.[1][2]

forma física

Lyophilized from a 0.2 μm filtered solution of 35% acetonitrile and 0.1% TFA.

Nota de análise

The biological activity is measured by its ability to inhibit recombinant human lGF-II on MCF-7 cells.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
SLCK1963
020M1205
099K1464
049K1407
117K1347

Não está vendo a versão correta?

Se precisar de uma versão específica, você pode procurar um certificado específico pelo número do lote ou da remessa.

Pesquise por COA

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Hye Suk Kang et al.
The Biochemical journal, 467(3), 453-460 (2015-02-20)
Insulin-like growth factor (IGF)-binding protein-2 (IGFBP-2), one of the most abundant circulating IGFBPs, is known to attenuate the biological action of IGF-1. Although the effect of IGFBP-2 in preventing metabolic disorders is well known, its regulatory mechanism remains unclear. In
Xinchun Shen et al.
The Journal of biological chemistry, 290(18), 11578-11590 (2015-03-20)
Insulin-like growth factor-binding protein-2 (IGFBP-2) functions coordinately with IGF-I to stimulate cellular proliferation and differentiation. IGFBP-2 binds to receptor tyrosine phosphatase β (RPTPβ), and this binding in conjunction with IGF-I receptor stimulation induces RPTPβ polymerization leading to phosphatase and tensin
Gang Xi et al.
Endocrinology, 154(11), 4146-4157 (2013-08-29)
IGF-binding protein (IGFBP)-2 overexpression confers resistance to high-fat feeding and inhibits the differentiation of preadipocytes in vitro. However, whether administration of IGFBP-2 can regulate adipogenesis in vivo and the domains that mediate this response have not been defined. IGFBP-2 contains
Gang Xi et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 29(11), 2427-2438 (2014-05-20)
Insulin-like growth factor binding protein 2 (IGFBP-2) is important for acquisition of normal bone mass in mice; however, the mechanism by which IGFBP-2 functions is not defined. These studies investigated the role of IGFBP-2 in stimulating osteoblast differentiation. MC-3T3 preosteoblasts

Questions

Reviews

No rating value

Active Filters

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica