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D7385

Sigma-Aldrich

Demecolcine

≥98% (HPLC)

Sinônimo(s):

N-Deacetyl-N-methylcolchicine

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About This Item

Fórmula empírica (Notação de Hill):
C21H25NO5
Número CAS:
477-30-5
Peso molecular:
371.43
Beilstein:
2822892
Número CE:
207-514-6
Número MDL:
MFCD00075459
Código UNSPSC:
12171500
ID de substância PubChem:
24894128
NACRES:
NA.47

Nível de qualidade

200

Ensaio

≥98% (HPLC)

forma

powder

pf

184 °C

solubilidade

chloroform: 10 mg/mL
ethanol: soluble

aplicação(ões)

diagnostic assay manufacturing
hematology
histology

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CN[C@H]1CCc2cc(OC)c(OC)c(OC)c2C3=CC=C(OC)C(=O)C=C13

InChI

1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3/t15-/m0/s1

chave InChI

NNJPGOLRFBJNIW-HNNXBMFYSA-N

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Aplicação

Demecolcine has been used as a microtubule depolymerizing agent. It has also been used to inhibit mitotic division.

Ações bioquímicas/fisiológicas

Often in karyotyping and cell cycle research it is desirable to increase the yield of mitotic cells in a particular phase of the cell cycle. This can be achieved in a variety of ways with the most popular being the use of a cell cycle synchronizing agent such as demecolcine. Demecolcine will arrest cells in metaphase with no remarkable effect on the biochemical events in mitotic cells or in synchronized G1 and S phase cells. White blood cells are often treated with demecolcine to arrest cells in metaphase.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H300

Declarações de precaução

P264 - P270 - P301 + P310 - P405 - P501

Classificações de perigo

Acute Tox. 2 Oral

Código de classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Sigma-Aldrich

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Sigma-Aldrich

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Flow cytometric discrimination of mitotic nuclei by right-angle light scatter.
Zucker RM, et al.
Cytometry, 9, 226-231 (1988)
The Drosophila microtubule-associated protein mars stabilizes mitotic spindles by crosslinking microtubules through its N-terminal region.
Zhang G, et al.
PLoS ONE, 8, e60596-e60596 (2013)
Mathew J Thayer
BioEssays : news and reviews in molecular, cellular and developmental biology, 34(9), 760-770 (2012-06-19)
Recent studies indicate that mammalian chromosomes contain discrete cis-acting loci that control replication timing, mitotic condensation, and stability of entire chromosomes. Disruption of the large non-coding RNA gene ASAR6 results in late replication, an under-condensed appearance during mitosis, and structural
Hailing Yang et al.
The Journal of biological chemistry, 285(42), 32242-32250 (2010-08-11)
Drugs that target microtubules are thought to inhibit cell division and cell migration by suppressing dynamic instability, a "search and capture" behavior that allows microtubules to probe their environment. Here, we report that subtoxic drug concentrations are sufficient to inhibit
Aleksandra Vančevska et al.
The EMBO journal, 39(7), e102668-e102668 (2020-02-23)
Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMCHD1) has been implicated in X-chromosome inactivation, imprinting, and DNA damage repair, and mutations in SMCHD1 can cause facioscapulohumeral muscular dystrophy. More recently, SMCHD1 has also been identified as a component
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